Peripheral clock gene expression in CS mice with bimodal locomotor rhythms

CS mice show unique properties of circadian rhythms: unstable free-running periods and distinct bimodal rhythms (similar to rhythm splitting, but hereafter referred to as bimodal rhythms) under constant darkness. In the present study, we compared clock-related gene expression ( mPer1, mBmal1 and Dbp...

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Bibliographic Details
Published in:Neuroscience research 2006-04, Vol.54 (4), p.295-301
Main Authors: Watanabe, Tsuyoshi, Kojima, Mayumi, Tomida, Shigeru, Nakamura, Takahiro J., Yamamura, Takashi, Nakao, Nobuhiro, Yasuo, Shinobu, Yoshimura, Takashi, Ebihara, Shizufumi
Format: Article
Language:English
Subjects:
Adrenal Glands - metabolism
Animals
Cell Cycle Proteins
Circadian rhythm
Circadian Rhythm - genetics
Clock genes
CS mice
DNA-Binding Proteins - biosynthesis
Gene Expression
Liver - metabolism
Male
Mice
Mice, Inbred C57BL
Motor Activity
Myocardium - metabolism
Nuclear Proteins - biosynthesis
Organ Specificity
Period Circadian Proteins
Peripheral clocks
Restricted feeding
Species Specificity
Suprachiasmatic nucleus
Suprachiasmatic Nucleus - metabolism
Transcription Factors - biosynthesis
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Summary:CS mice show unique properties of circadian rhythms: unstable free-running periods and distinct bimodal rhythms (similar to rhythm splitting, but hereafter referred to as bimodal rhythms) under constant darkness. In the present study, we compared clock-related gene expression ( mPer1, mBmal1 and Dbp) in the SCN and peripheral tissues (liver, adrenal gland and heart) between CS and C57BL/6J mice. In spite of normal robust oscillation in the SCN of both mice, behavioral rhythms and peripheral rhythms of clock-related genes were significantly different between these mice. However, when daytime restricted feeding was given, no essential differences between the two strains were observed. These results indicate that unusual circadian behaviors and peripheral gene expression in CS mice do not depend on the SCN but rather mechanisms outside of the SCN.
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2005.12.009