Oxidative stress in diabetes: A mechanistic overview of its effects on atherogenesis and myocardial dysfunction

Diabetes is a major risk factor for atherosclerosis. Atherogenesis involves endothelial dysfunction, activation and injury, inflammation, and smooth muscle cell migration and proliferation. Platelet activation in the narrowed arteries is the most proximate event in the culmination of an acute event...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2006-01, Vol.38 (5), p.794-803
Main Authors: Mehta, Jawahar L., Rasouli, Neda, Sinha, Anjan K., Molavi, Behzad
Format: Article
Language:English
Subjects:
Animals
Antioxidants - physiology
Atherosclerosis
Atherosclerosis - etiology
Cardiomyopathies - etiology
Diabetes
Diabetes Complications - physiopathology
Humans
Inflammation - physiopathology
Insulin Resistance - physiology
Mitochondria - physiology
Oxidative stress
Oxidative Stress - physiology
Reactive oxygen species
Reactive Oxygen Species - metabolism
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Summary:Diabetes is a major risk factor for atherosclerosis. Atherogenesis involves endothelial dysfunction, activation and injury, inflammation, and smooth muscle cell migration and proliferation. Platelet activation in the narrowed arteries is the most proximate event in the culmination of an acute event such as acute myocardial infraction and stroke. Hyperglycemia is associated with all these adverse events in the process of genesis of atherosclerosis. The effect of diabetes (hyperglycemia) is mediated in large part by the state of enhanced oxidative stress, which is not counter-balanced by endogenous antioxidants. This paper reviews the ignition of oxidative stress in diabetes and the mediation of events leading to atherogenesis.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2005.12.008