Surfactant-Assisted Synthesis of Water-Soluble and Biocompatible Semiconductor Quantum Dot Micelles

We report a simple, rapid approach to synthesize water-soluble and biocompatible fluorescent quantum dot (QD) micelles by encapsulation of monodisperse, hydrophobic QDs within surfactant/lipid micelles. Analyses of UV−vis and photo luminescence spectra, along with transmission electron microscopy, i...

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Bibliographic Details
Published in:Nano letters 2005-04, Vol.5 (4), p.645-648
Main Authors: Fan, Hongyou, Leve, Erik W, Scullin, Chessa, Gabaldon, John, Tallant, David, Bunge, Scott, Boyle, Tim, Wilson, Michael C, Brinker, C. Jeffrey
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemical synthesis
Cadmium Compounds - chemistry
Cells, Cultured
Chemistry
Colloidal state and disperse state
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
General and physical chemistry
General, apparatus, technics of preparation
Hippocampus - cytology
Materials science
Micelles
Nanoscale materials and structures: fabrication and characterization
Neurons - physiology
Physics
Quantum Dots
Rats
Selenium Compounds - chemistry
Semiconductors
Surface-Active Agents - chemistry
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Summary:We report a simple, rapid approach to synthesize water-soluble and biocompatible fluorescent quantum dot (QD) micelles by encapsulation of monodisperse, hydrophobic QDs within surfactant/lipid micelles. Analyses of UV−vis and photo luminescence spectra, along with transmission electron microscopy, indicate that the water-soluble semiconductor QD micelles are monodisperse and retain the optical properties of the original hydrophobic QDs. The QD micelles were shown to be biocompatible and exhibited little or no aggregation when taken up by cultured rat hippocampal neurons.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl050017l