The ribosome-recycling step: consensus or controversy?

Ribosome recycling, the last step in translation, is now accepted as an essential process for prokaryotes. In 2005, three laboratories showed that ribosome-recycling factor (RRF) and elongation factor G (EF-G) cause dissociation of ribosomes into subunits, solving the long-standing problem of how th...

Full description

Saved in:
Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 2006-03, Vol.31 (3), p.143-149
Main Authors: Hirokawa, Go, Demeshkina, Natalia, Iwakura, Nobuhiro, Kaji, Hideko, Kaji, Akira
Format: Article
Language:English
Subjects:
Biological Transport
Protein Binding
Protein Subunits - chemistry
Protein Subunits - metabolism
Ribosomes - chemistry
Ribosomes - metabolism
RNA, Messenger - metabolism
RNA, Transfer - chemistry
RNA, Transfer - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ribosome recycling, the last step in translation, is now accepted as an essential process for prokaryotes. In 2005, three laboratories showed that ribosome-recycling factor (RRF) and elongation factor G (EF-G) cause dissociation of ribosomes into subunits, solving the long-standing problem of how this essential step of translation occurs. However, there remains ongoing controversy regarding the other actions of RRF and EF-G during ribosome recycling. We propose that the available data are consistent with the notion that RRF and EF-G not only split ribosomes into subunits but also participate directly in the release of deacylated tRNA and mRNA for the next round of translation.
ISSN:0968-0004
1362-4326
DOI:10.1016/j.tibs.2006.01.007