Human Blood Group Genes 2004: Chromosomal Locations and Cloning Strategies

Of the 29 human blood group system genes, 27 have been localized to 14 autosomes and 2 have been assigned to the X chromosome. It is remarkable that 28 of the 29 system genes have now been localized to a single cytogenetic band on a specific chromosome. In this review, we summarize the chromosomal l...

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Bibliographic Details
Published in:Transfusion medicine reviews 2005, Vol.19 (1), p.45-57
Main Authors: Lögdberg, Lennart, Reid, Marion E., Lamont, Ryan E., Zelinski, Teresa
Format: Article
Language:English
Subjects:
Blood Group Antigens - genetics
Chromosome Mapping - methods
Chromosomes, Human, X
Cloning, Molecular
Cytogenetics - methods
Erythrocytes - metabolism
Genetic Techniques
Humans
Polymorphism, Genetic
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Summary:Of the 29 human blood group system genes, 27 have been localized to 14 autosomes and 2 have been assigned to the X chromosome. It is remarkable that 28 of the 29 system genes have now been localized to a single cytogenetic band on a specific chromosome. In this review, we summarize the chromosomal locations and cloning strategies used for those genes encoding blood group systems. We highlight such information about the 3 most recently defined blood group systems (I, GLOB, and GIL). In addition, we provide new information about 2 older blood group systems (SC and RAPH) whose polymorphisms have been defined in cloned genes.
ISSN:0887-7963
1532-9496
DOI:10.1016/j.tmrv.2004.09.007