Severe Refractory Status Epilepticus Owing to Presumed Encephalitis

The severe refractory type of status epilepticus is very rare in the pediatric population. Eight children with the severe refractory type of status epilepticus owing to presumed encephalitis are described. The age at the onset of status epilepticus of the eight study children ranged between 2.5 and...

Full description

Saved in:
Bibliographic Details
Published in:Journal of child neurology 2005-03, Vol.20 (3), p.184-187
Main Authors: Kramer, Uri, Shorer, Zamir, Ben-Zeev, Bruria, Lerman-Sagie, Tally, Goldberg-Stern, Hadassa, Lahat, Eli
Format: Article
Language:English
Subjects:
Adolescent
Anesthetics - administration & dosage
Anticonvulsants - administration & dosage
Brain - pathology
Child
Child, Preschool
Combined Modality Therapy
Electroencephalography
Encephalitis - complications
Encephalitis - pathology
Encephalitis - physiopathology
Female
Follow-Up Studies
Glucocorticoids - administration & dosage
Humans
Immunoglobulins, Intravenous - administration & dosage
Male
Respiration, Artificial
Retrospective Studies
Severity of Illness Index
Status Epilepticus - diagnosis
Status Epilepticus - etiology
Status Epilepticus - therapy
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The severe refractory type of status epilepticus is very rare in the pediatric population. Eight children with the severe refractory type of status epilepticus owing to presumed encephalitis are described. The age at the onset of status epilepticus of the eight study children ranged between 2.5 and 15 years. Seven of the eight children presented with fever several days prior to the onset of seizures. A comprehensive clinical and laboratory investigation failed to delineate a cause for their seizures. Burst suppression coma was induced by pentothal, midazolam, propofol, or ketamine in all of the children. The mean duration of anesthesia was 28 days (range 4—62 days), but the seizures persisted in spite of repeated burst suppression cycles in all of them. Two children died. Four of the surviving children continued to suffer from seizures, and cognitive sequelae were present throughout follow-up in four children. In summary, the severe refractory type of status epilepticus of the acute symptomatic type owing to relatively mild encephalitis carries a high mortality rate and poor morbidity in terms of seizures and cognition at follow-up. ( J Child Neurol 2005;20:184—187).
ISSN:0883-0738
1708-8283
DOI:10.1177/08830738050200030301