Synthesis and structure-activity relationship of β-defensins, multi-functional peptides of the immune system

β‐defensins are a large family of multiple disulfide‐bonded peptides occurring in mammals and birds. They play an important role in the innate immune system, directly killing microbial organisms. Recent research has demonstrated that β‐defensins are important for other biological functions beyond an...

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Bibliographic Details
Published in:Journal of peptide science 2006-04, Vol.12 (4), p.243-257
Main Authors: Klüver, Enno, Adermann, Knut, Schulz, Axel
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Anti-Infective Agents - chemical synthesis
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
antimicrobial peptide
beta-defensin
beta-Defensins - chemical synthesis
beta-Defensins - chemistry
beta-Defensins - pharmacology
defensin
disulfide bond
Humans
immune system
Microbial Sensitivity Tests
Models, Molecular
Molecular Sequence Data
Sequence Homology, Amino Acid
structure-activity relation
Structure-Activity Relationship
synthesis
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Summary:β‐defensins are a large family of multiple disulfide‐bonded peptides occurring in mammals and birds. They play an important role in the innate immune system, directly killing microbial organisms. Recent research has demonstrated that β‐defensins are important for other biological functions beyond antimicrobial effects, including inhibition of viral infection, interaction with Toll‐like receptors, chemotactic effects, and sperm function. The corresponding broad spectrum of activities makes this peptide class an important subject and tool in immunologic research. In this review, we summarize the current status of the routes to obtain synthetic β‐defensins, their major structural properties and structure–activity relationship. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd.
ISSN:1075-2617
1099-1387
DOI:10.1002/psc.749