Preparation and antimicrobial activity of gelatin microparticles containing propolis against oral pathogens

Gelatin microparticles containing propolis ethanolic extractive solution were prepared by spray-drying technique. Particles with regular morphology, mean diameter ranging of 2.27 microm to 2.48 microm, and good entrapment efficiency for propolis were obtained. The in vitro antimicrobial activity of...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2006-02, Vol.32 (2), p.229-238
Main Authors: BRUSCHI, M. L, LARA, E. H. G, MARTINS, C. H. G, VINHOLIS, A. H. C, CASEMIRO, L. A, PANZERL, H, GREMIAO, M. P. D
Format: Article
Language:English
Subjects:
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - therapeutic use
Biological and medical sciences
Candida albicans - drug effects
Drug Carriers
Ethanol - chemistry
Gelatin - chemistry
General pharmacology
Lactobacillus casei - drug effects
Medical sciences
Microbial Sensitivity Tests
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Propolis - administration & dosage
Propolis - therapeutic use
Streptococcaceae - drug effects
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Summary:Gelatin microparticles containing propolis ethanolic extractive solution were prepared by spray-drying technique. Particles with regular morphology, mean diameter ranging of 2.27 microm to 2.48 microm, and good entrapment efficiency for propolis were obtained. The in vitro antimicrobial activity of microparticles was evaluated against microorganisms of oral importance (Enterococcus faecalis, Streptococcus salivarius, Streptococcus sanguinis, Streptococcus mitis, Streptococcus mutans, Streptococcus sobrinus, Candida albicans, and Lactobacillus casei). The utilized techniques were diffusion in agar and determination of minimum inhibitory concentration. The choice of the method to evaluate the antimicrobial activity of microparticles showed be very important. The microparticles displayed activity against all tested strains of similar way to the propolis, showing greater activity against the strains of E. salivarius, S. sanguinis, S. mitis, and C. albicans.
ISSN:0363-9045
1520-5762
DOI:10.1080/03639040500466312