Loading…
Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal Cancer
Purpose: Human kallikrein gene 6 ( KLK6 ) is a member of the human kallikrein gene family, and recent studies have found that many kallikreins have altered expression patterns in various malignancies. The purpose of the current study was to quantify the expression of KLK6 in malignant and benign col...
Saved in:
| Published in: | Clinical cancer research 2005-04, Vol.11 (8), p.2889-2893 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c467t-2d9a2e64b67798d228930dabfec5f562783084f053ea0278446ef65836cf79e43 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c467t-2d9a2e64b67798d228930dabfec5f562783084f053ea0278446ef65836cf79e43 |
| container_end_page | 2893 |
| container_issue | 8 |
| container_start_page | 2889 |
| container_title | Clinical cancer research |
| container_volume | 11 |
| creator | OGAWA, Kazuhiko UTSUNOMIYA, Tohru MIMORI, Koshi TANAKA, Fumiaki INOUE, Hiroshi NAGAHARA, Hisashi MURAYAMA, Sadayuki MORI, Masaki |
| description | Purpose: Human kallikrein gene 6 ( KLK6 ) is a member of the human kallikrein gene family, and recent studies have found that many kallikreins have altered expression
patterns in various malignancies. The purpose of the current study was to quantify the expression of KLK6 in malignant and benign colorectal tissues and to statistically analyze whether KLK6 expression levels correlate with clinicopathologic variables and prognosis in patients with colorectal cancer.
Experimental Designs: Paired colorectal tissue samples from cancerous and corresponding noncancerous tissues were obtained from 63 patients with
colorectal cancer who underwent surgical resection. Quantitative analyses of KLK6 mRNA expression were done using real-time quantitative reverse transcription-PCR.
Results: KLK6 mRNA overexpression in cancerous tissues compared with normal counterparts was observed in 57 of 63 (90%) patients. The mean
expression level of KLK6 mRNA in cancerous tissues was significantly higher than that in noncancerous tissues ( P < 0.0001). Elevated KLK6 expression was significantly correlated with serosal invasion ( P < 0.05), liver metastasis ( P < 0.05), and advanced Duke's stage ( P < 0.01). Furthermore, patients with high KLK6 expression had a significantly poorer actuarial overall survival than patients with low KLK6 expression (5-year overall survival rates: 54% and 73%, respectively, P < 0.05).
Conclusions: The results of this study indicated that KLK6 mRNA expression was significantly higher in cancerous than in noncancerous colorectal tissues, and high expression of KLK6 mRNA correlated with serosal invasion, liver metastasis, advanced Duke's stage, and a poor prognosis for patients with colorectal
cancer. |
| doi_str_mv | 10.1158/1078-0432.CCR-04-2281 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67747711</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17341954</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-2d9a2e64b67798d228930dabfec5f562783084f053ea0278446ef65836cf79e43</originalsourceid><addsrcrecordid>eNqFkUtvEzEUha0K1JbSn1DkTSs2U-zxc5bVqA9EAanAFstxrhPTiSe1EwH_njskqEtWPrY-H_ueQ8gZZ5ecK_uOM2MbJkV72fcPKJq2tfyAHHOlTCNarV6g_scckVe1_mCMS87kITlCA2GMsMfkez-knIIf6Je0yCmizAHoGOndduUz_eCHIT0WSJneQgaq6UeoFfICCn34dEWvf60LHqQxU0T6cRgLhA3a9ZNPeU1eRj9UON2vJ-TbzfXX_q65_3z7vr-6b4LUZtO08863oOVMG9PZOY7SCTb3swhBRaVbYwWzMjIlwDPcSakhahxCh2g6kOKEXOx812V82kLduFWqAYbBZxi31aGvNIbz_4LcCMk7NTmqHRjKWGuB6NYlrXz57ThzUwNuStdN6TpsAIWbGsB7b_YPbGcrmD_f2keOwPke8BVzjwWDSvWZ04bpTink3u64ZVosf6YC7m81BeMGX8ISP-Gsay1G9Qezjpr2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17341954</pqid></control><display><type>article</type><title>Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal Cancer</title><source>Freely Accessible Science Journals - check A-Z of ejournals</source><creator>OGAWA, Kazuhiko ; UTSUNOMIYA, Tohru ; MIMORI, Koshi ; TANAKA, Fumiaki ; INOUE, Hiroshi ; NAGAHARA, Hisashi ; MURAYAMA, Sadayuki ; MORI, Masaki</creator><creatorcontrib>OGAWA, Kazuhiko ; UTSUNOMIYA, Tohru ; MIMORI, Koshi ; TANAKA, Fumiaki ; INOUE, Hiroshi ; NAGAHARA, Hisashi ; MURAYAMA, Sadayuki ; MORI, Masaki</creatorcontrib><description>Purpose: Human kallikrein gene 6 ( KLK6 ) is a member of the human kallikrein gene family, and recent studies have found that many kallikreins have altered expression
patterns in various malignancies. The purpose of the current study was to quantify the expression of KLK6 in malignant and benign colorectal tissues and to statistically analyze whether KLK6 expression levels correlate with clinicopathologic variables and prognosis in patients with colorectal cancer.
Experimental Designs: Paired colorectal tissue samples from cancerous and corresponding noncancerous tissues were obtained from 63 patients with
colorectal cancer who underwent surgical resection. Quantitative analyses of KLK6 mRNA expression were done using real-time quantitative reverse transcription-PCR.
Results: KLK6 mRNA overexpression in cancerous tissues compared with normal counterparts was observed in 57 of 63 (90%) patients. The mean
expression level of KLK6 mRNA in cancerous tissues was significantly higher than that in noncancerous tissues ( P < 0.0001). Elevated KLK6 expression was significantly correlated with serosal invasion ( P < 0.05), liver metastasis ( P < 0.05), and advanced Duke's stage ( P < 0.01). Furthermore, patients with high KLK6 expression had a significantly poorer actuarial overall survival than patients with low KLK6 expression (5-year overall survival rates: 54% and 73%, respectively, P < 0.05).
Conclusions: The results of this study indicated that KLK6 mRNA expression was significantly higher in cancerous than in noncancerous colorectal tissues, and high expression of KLK6 mRNA correlated with serosal invasion, liver metastasis, advanced Duke's stage, and a poor prognosis for patients with colorectal
cancer.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-04-2281</identifier><identifier>PMID: 15837738</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Aged ; Antineoplastic agents ; Biological and medical sciences ; colorectal neoplasms ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Expression Regulation, Neoplastic ; Humans ; kallikrein 6 ; Kallikreins - genetics ; KLK6 ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Pharmacology. Drug treatments ; Prognosis ; prognostic factors ; quantitative real-time PCR ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Tumors</subject><ispartof>Clinical cancer research, 2005-04, Vol.11 (8), p.2889-2893</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-2d9a2e64b67798d228930dabfec5f562783084f053ea0278446ef65836cf79e43</citedby><cites>FETCH-LOGICAL-c467t-2d9a2e64b67798d228930dabfec5f562783084f053ea0278446ef65836cf79e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16706955$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15837738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OGAWA, Kazuhiko</creatorcontrib><creatorcontrib>UTSUNOMIYA, Tohru</creatorcontrib><creatorcontrib>MIMORI, Koshi</creatorcontrib><creatorcontrib>TANAKA, Fumiaki</creatorcontrib><creatorcontrib>INOUE, Hiroshi</creatorcontrib><creatorcontrib>NAGAHARA, Hisashi</creatorcontrib><creatorcontrib>MURAYAMA, Sadayuki</creatorcontrib><creatorcontrib>MORI, Masaki</creatorcontrib><title>Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal Cancer</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: Human kallikrein gene 6 ( KLK6 ) is a member of the human kallikrein gene family, and recent studies have found that many kallikreins have altered expression
patterns in various malignancies. The purpose of the current study was to quantify the expression of KLK6 in malignant and benign colorectal tissues and to statistically analyze whether KLK6 expression levels correlate with clinicopathologic variables and prognosis in patients with colorectal cancer.
Experimental Designs: Paired colorectal tissue samples from cancerous and corresponding noncancerous tissues were obtained from 63 patients with
colorectal cancer who underwent surgical resection. Quantitative analyses of KLK6 mRNA expression were done using real-time quantitative reverse transcription-PCR.
Results: KLK6 mRNA overexpression in cancerous tissues compared with normal counterparts was observed in 57 of 63 (90%) patients. The mean
expression level of KLK6 mRNA in cancerous tissues was significantly higher than that in noncancerous tissues ( P < 0.0001). Elevated KLK6 expression was significantly correlated with serosal invasion ( P < 0.05), liver metastasis ( P < 0.05), and advanced Duke's stage ( P < 0.01). Furthermore, patients with high KLK6 expression had a significantly poorer actuarial overall survival than patients with low KLK6 expression (5-year overall survival rates: 54% and 73%, respectively, P < 0.05).
Conclusions: The results of this study indicated that KLK6 mRNA expression was significantly higher in cancerous than in noncancerous colorectal tissues, and high expression of KLK6 mRNA correlated with serosal invasion, liver metastasis, advanced Duke's stage, and a poor prognosis for patients with colorectal
cancer.</description><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>colorectal neoplasms</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>kallikrein 6</subject><subject>Kallikreins - genetics</subject><subject>KLK6</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>prognostic factors</subject><subject>quantitative real-time PCR</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkUtvEzEUha0K1JbSn1DkTSs2U-zxc5bVqA9EAanAFstxrhPTiSe1EwH_njskqEtWPrY-H_ueQ8gZZ5ecK_uOM2MbJkV72fcPKJq2tfyAHHOlTCNarV6g_scckVe1_mCMS87kITlCA2GMsMfkez-knIIf6Je0yCmizAHoGOndduUz_eCHIT0WSJneQgaq6UeoFfICCn34dEWvf60LHqQxU0T6cRgLhA3a9ZNPeU1eRj9UON2vJ-TbzfXX_q65_3z7vr-6b4LUZtO08863oOVMG9PZOY7SCTb3swhBRaVbYwWzMjIlwDPcSakhahxCh2g6kOKEXOx812V82kLduFWqAYbBZxi31aGvNIbz_4LcCMk7NTmqHRjKWGuB6NYlrXz57ThzUwNuStdN6TpsAIWbGsB7b_YPbGcrmD_f2keOwPke8BVzjwWDSvWZ04bpTink3u64ZVosf6YC7m81BeMGX8ISP-Gsay1G9Qezjpr2</recordid><startdate>20050415</startdate><enddate>20050415</enddate><creator>OGAWA, Kazuhiko</creator><creator>UTSUNOMIYA, Tohru</creator><creator>MIMORI, Koshi</creator><creator>TANAKA, Fumiaki</creator><creator>INOUE, Hiroshi</creator><creator>NAGAHARA, Hisashi</creator><creator>MURAYAMA, Sadayuki</creator><creator>MORI, Masaki</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050415</creationdate><title>Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal Cancer</title><author>OGAWA, Kazuhiko ; UTSUNOMIYA, Tohru ; MIMORI, Koshi ; TANAKA, Fumiaki ; INOUE, Hiroshi ; NAGAHARA, Hisashi ; MURAYAMA, Sadayuki ; MORI, Masaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-2d9a2e64b67798d228930dabfec5f562783084f053ea0278446ef65836cf79e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>colorectal neoplasms</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>kallikrein 6</topic><topic>Kallikreins - genetics</topic><topic>KLK6</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>prognostic factors</topic><topic>quantitative real-time PCR</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OGAWA, Kazuhiko</creatorcontrib><creatorcontrib>UTSUNOMIYA, Tohru</creatorcontrib><creatorcontrib>MIMORI, Koshi</creatorcontrib><creatorcontrib>TANAKA, Fumiaki</creatorcontrib><creatorcontrib>INOUE, Hiroshi</creatorcontrib><creatorcontrib>NAGAHARA, Hisashi</creatorcontrib><creatorcontrib>MURAYAMA, Sadayuki</creatorcontrib><creatorcontrib>MORI, Masaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OGAWA, Kazuhiko</au><au>UTSUNOMIYA, Tohru</au><au>MIMORI, Koshi</au><au>TANAKA, Fumiaki</au><au>INOUE, Hiroshi</au><au>NAGAHARA, Hisashi</au><au>MURAYAMA, Sadayuki</au><au>MORI, Masaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal Cancer</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2005-04-15</date><risdate>2005</risdate><volume>11</volume><issue>8</issue><spage>2889</spage><epage>2893</epage><pages>2889-2893</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: Human kallikrein gene 6 ( KLK6 ) is a member of the human kallikrein gene family, and recent studies have found that many kallikreins have altered expression
patterns in various malignancies. The purpose of the current study was to quantify the expression of KLK6 in malignant and benign colorectal tissues and to statistically analyze whether KLK6 expression levels correlate with clinicopathologic variables and prognosis in patients with colorectal cancer.
Experimental Designs: Paired colorectal tissue samples from cancerous and corresponding noncancerous tissues were obtained from 63 patients with
colorectal cancer who underwent surgical resection. Quantitative analyses of KLK6 mRNA expression were done using real-time quantitative reverse transcription-PCR.
Results: KLK6 mRNA overexpression in cancerous tissues compared with normal counterparts was observed in 57 of 63 (90%) patients. The mean
expression level of KLK6 mRNA in cancerous tissues was significantly higher than that in noncancerous tissues ( P < 0.0001). Elevated KLK6 expression was significantly correlated with serosal invasion ( P < 0.05), liver metastasis ( P < 0.05), and advanced Duke's stage ( P < 0.01). Furthermore, patients with high KLK6 expression had a significantly poorer actuarial overall survival than patients with low KLK6 expression (5-year overall survival rates: 54% and 73%, respectively, P < 0.05).
Conclusions: The results of this study indicated that KLK6 mRNA expression was significantly higher in cancerous than in noncancerous colorectal tissues, and high expression of KLK6 mRNA correlated with serosal invasion, liver metastasis, advanced Duke's stage, and a poor prognosis for patients with colorectal
cancer.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15837738</pmid><doi>10.1158/1078-0432.CCR-04-2281</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 2005-04, Vol.11 (8), p.2889-2893 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67747711 |
| source | Freely Accessible Science Journals - check A-Z of ejournals |
| subjects | Aged Antineoplastic agents Biological and medical sciences colorectal neoplasms Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Humans kallikrein 6 Kallikreins - genetics KLK6 Lymphatic Metastasis Male Medical sciences Middle Aged Neoplasm Invasiveness Neoplasm Staging Pharmacology. Drug treatments Prognosis prognostic factors quantitative real-time PCR Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors |
| title | Clinical Significance of Human Kallikrein Gene 6 Messenger RNA Expression in Colorectal Cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T13%3A26%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20Significance%20of%20Human%20Kallikrein%20Gene%206%20Messenger%20RNA%20Expression%20in%20Colorectal%20Cancer&rft.jtitle=Clinical%20cancer%20research&rft.au=OGAWA,%20Kazuhiko&rft.date=2005-04-15&rft.volume=11&rft.issue=8&rft.spage=2889&rft.epage=2893&rft.pages=2889-2893&rft.issn=1078-0432&rft.eissn=1557-3265&rft_id=info:doi/10.1158/1078-0432.CCR-04-2281&rft_dat=%3Cproquest_cross%3E17341954%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c467t-2d9a2e64b67798d228930dabfec5f562783084f053ea0278446ef65836cf79e43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17341954&rft_id=info:pmid/15837738&rfr_iscdi=true |