Progression of subclinical coronary atherosclerosis : Does obesity make a difference?

Obesity is associated with coronary artery calcification (CAC), a marker of the presence and extent of subclinical coronary atherosclerosis. Obesity adds incremental information in identifying those at higher risk of coronary heart disease to traditional risk factor assessment. The present study exa...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2005-04, Vol.111 (15), p.1877-1882
Main Authors: CASSIDY, Andrea E, BIELAK, Lawrence F, YAN ZHOU, SHEEDY, Patrick F, TURNER, Stephen T, BREEN, Jerome F, ARAOZ, Philip A, KULLO, Iftikhar J, XIHONG LIN, PEYSER, Patricia A
Format: Article
Language:English
Subjects:
Adult
Aged
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Body Mass Index
Body Weights and Measures
Cardiology. Vascular system
Coronary Artery Disease - epidemiology
Coronary Artery Disease - etiology
Coronary Artery Disease - pathology
Coronary heart disease
Data Collection
Disease Progression
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Heart
Humans
Linear Models
Male
Medical sciences
Middle Aged
Obesity - complications
Obesity - epidemiology
Risk Assessment
Risk Factors
Tomography, X-Ray Computed
Waist-Hip Ratio
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Summary:Obesity is associated with coronary artery calcification (CAC), a marker of the presence and extent of subclinical coronary atherosclerosis. Obesity adds incremental information in identifying those at higher risk of coronary heart disease to traditional risk factor assessment. The present study examined associations between obesity measures and progression of CAC in those at higher (> or =10%) and lower (30 years of age (243 men) had baseline and follow-up CAC measurements an average of 8.9 years apart. Multivariable linear regression models were fit to determine associations of obesity measures at baseline with progression of CAC defined as log(e) of the difference between follow-up and baseline CAC area plus 1 divided by time (in years) between examinations, adjusting for baseline CAC quantity, age, sex, baseline hypertension status, and baseline cholesterol level. Among 329 participants (74.3%) in the lower-risk group, waist circumference (P=0.024), waist-to-hip ratio (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000161820.40494.5D