Betaine Supplementation and Blood Lipids: Fact or Artifact?

Betaine supplementation in humans has been shown to lower plasma homocysteine concentrations in modestly hyperhomocysteinemic patients. Betaine treatment is associated with increased plasma low-density-lipoprotein (LDL) cholesterol, suggesting that although betaine supplementation lowers homocystein...

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Bibliographic Details
Published in:Nutrition reviews 2006-02, Vol.64 (2), p.77-79
Main Author: Zeisel, S.H
Format: Article
Language:English
Subjects:
betaine
Betaine - administration & dosage
Biological and medical sciences
blood lipids
Cardiovascular disease
cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - prevention & control
Dietary Supplements
Drug therapy
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
homocysteine
Homocysteine - blood
human health
Humans
Lipids
Lipids - blood
Lipotropic Agents - administration & dosage
low density lipoprotein
Plasma
risk factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Betaine supplementation in humans has been shown to lower plasma homocysteine concentrations in modestly hyperhomocysteinemic patients. Betaine treatment is associated with increased plasma low-density-lipoprotein (LDL) cholesterol, suggesting that although betaine supplementation lowers homocysteine, a risk factor for cardiovascular disease, changes in blood lipids may have a counterbalancing effect. However, whether the betaine effect on LDL concentration is a clinically significant problem that should change treatment options or is simply an artifact needs further study.
ISSN:0029-6643
1753-4887
DOI:10.1111/j.1753-4887.2006.tb00190.x