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Synthesis and characterization of a tetracycline–platinum (II) complex active against resistant bacteria
A tetracycline–platinum(II) complex, [PtCl 2(C 22H 24N 2O 8)], was synthesized and characterized by elemental analysis, conductivity and thermogravimetric analyses, and infrared spectroscopy. The interaction of tetracycline (Tc) with platinum(II) ions was also studied in aqueous solution by 1H NMR a...
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| Published in: | Journal of inorganic biochemistry 2005-05, Vol.99 (5), p.1001-1008 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c369t-386b14c8fbf7fc207a82a61c1f5d92228a121dcf245bad89ec9547d7da765baf3 |
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| cites | cdi_FETCH-LOGICAL-c369t-386b14c8fbf7fc207a82a61c1f5d92228a121dcf245bad89ec9547d7da765baf3 |
| container_end_page | 1008 |
| container_issue | 5 |
| container_start_page | 1001 |
| container_title | Journal of inorganic biochemistry |
| container_volume | 99 |
| creator | Chartone-Souza, Edmar Loyola, Thaís L. Bucciarelli-Rodriguez, Mônica Menezes, Maria Ã. de B.C. Rey, Nicolás A. Pereira-Maia, Elene C. |
| description | A tetracycline–platinum(II) complex, [PtCl
2(C
22H
24N
2O
8)], was synthesized and characterized by elemental analysis, conductivity and thermogravimetric analyses, and infrared spectroscopy. The interaction of tetracycline (Tc) with platinum(II) ions was also studied in aqueous solution by
1H NMR and circular dichroism spectroscopies. Tetracycline forms a 1:1 complex with platinum via the oxygen of the hydroxyl group at the A ring and that of the amide group. The complex is as efficient as tetracycline in inhibiting the growth of two
Escherichia coli sensitive bacterial strains and six times more potent against
E. coli HB101/pBR322, a bacterial strain resistant to tetracycline. This finding is very important because the use of tetracycline to treat bacterial infections has declined due to the emergence of resistant organisms. |
| doi_str_mv | 10.1016/j.jinorgbio.2005.01.004 |
| format | article |
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2(C
22H
24N
2O
8)], was synthesized and characterized by elemental analysis, conductivity and thermogravimetric analyses, and infrared spectroscopy. The interaction of tetracycline (Tc) with platinum(II) ions was also studied in aqueous solution by
1H NMR and circular dichroism spectroscopies. Tetracycline forms a 1:1 complex with platinum via the oxygen of the hydroxyl group at the A ring and that of the amide group. The complex is as efficient as tetracycline in inhibiting the growth of two
Escherichia coli sensitive bacterial strains and six times more potent against
E. coli HB101/pBR322, a bacterial strain resistant to tetracycline. This finding is very important because the use of tetracycline to treat bacterial infections has declined due to the emergence of resistant organisms.</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/j.jinorgbio.2005.01.004</identifier><identifier>PMID: 15833322</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antimicrobial activity ; Bacterial resistance ; Circular Dichroism ; Escherichia coli - drug effects ; Organoplatinum Compounds - chemical synthesis ; Organoplatinum Compounds - chemistry ; Organoplatinum Compounds - pharmacology ; Synthesis ; Tetracycline Resistance ; Tetracyclines - chemical synthesis ; Tetracyclines - chemistry ; Tetracyclines - pharmacology ; Tetracycline–platinum complex</subject><ispartof>Journal of inorganic biochemistry, 2005-05, Vol.99 (5), p.1001-1008</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-386b14c8fbf7fc207a82a61c1f5d92228a121dcf245bad89ec9547d7da765baf3</citedby><cites>FETCH-LOGICAL-c369t-386b14c8fbf7fc207a82a61c1f5d92228a121dcf245bad89ec9547d7da765baf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15833322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chartone-Souza, Edmar</creatorcontrib><creatorcontrib>Loyola, Thaís L.</creatorcontrib><creatorcontrib>Bucciarelli-Rodriguez, Mônica</creatorcontrib><creatorcontrib>Menezes, Maria Ã. de B.C.</creatorcontrib><creatorcontrib>Rey, Nicolás A.</creatorcontrib><creatorcontrib>Pereira-Maia, Elene C.</creatorcontrib><title>Synthesis and characterization of a tetracycline–platinum (II) complex active against resistant bacteria</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>A tetracycline–platinum(II) complex, [PtCl
2(C
22H
24N
2O
8)], was synthesized and characterized by elemental analysis, conductivity and thermogravimetric analyses, and infrared spectroscopy. The interaction of tetracycline (Tc) with platinum(II) ions was also studied in aqueous solution by
1H NMR and circular dichroism spectroscopies. Tetracycline forms a 1:1 complex with platinum via the oxygen of the hydroxyl group at the A ring and that of the amide group. The complex is as efficient as tetracycline in inhibiting the growth of two
Escherichia coli sensitive bacterial strains and six times more potent against
E. coli HB101/pBR322, a bacterial strain resistant to tetracycline. This finding is very important because the use of tetracycline to treat bacterial infections has declined due to the emergence of resistant organisms.</description><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial activity</subject><subject>Bacterial resistance</subject><subject>Circular Dichroism</subject><subject>Escherichia coli - drug effects</subject><subject>Organoplatinum Compounds - chemical synthesis</subject><subject>Organoplatinum Compounds - chemistry</subject><subject>Organoplatinum Compounds - pharmacology</subject><subject>Synthesis</subject><subject>Tetracycline Resistance</subject><subject>Tetracyclines - chemical synthesis</subject><subject>Tetracyclines - chemistry</subject><subject>Tetracyclines - pharmacology</subject><subject>Tetracycline–platinum complex</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkM1O3DAURq2qqEyBV6BeVe0iqX-SOLNEqC0jIXXRdm059jU4Suyp7UEMK96BN-yT4NGMYMnK0vX5vqt7EPpESU0J7b6N9eh8iDeDCzUjpK0JrQlp3qEF7QWvOG-a92hRSFYRyptj9DGlkRSwbcQHdEzbnnPO2AKNv7c-30JyCStvsL5VUekM0T2o7ILHwWKFM-Qy3erJefj_-LSeyp_fzPjLavUV6zCvJ7jHJebuAKsb5XzKOO46s_IZD_tCdYqOrJoSnB3eE_T3x_c_l1fV9a-fq8uL60rzbpkr3ncDbXRvByusZkSonqmOampbs2SM9YoyarRlTTso0y9BL8tRRhglujKx_AR93veuY_i3gZTl7JKGaVIewibJToim7wQpoNiDOoaUIli5jm5WcSspkTvNcpQvmuVOsyRUFs0leX5YsRlmMK-5g9cCXOwBKIfeOYgyaQdeg3ERdJYmuDeXPAMd3pYs</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Chartone-Souza, Edmar</creator><creator>Loyola, Thaís L.</creator><creator>Bucciarelli-Rodriguez, Mônica</creator><creator>Menezes, Maria Ã. de B.C.</creator><creator>Rey, Nicolás A.</creator><creator>Pereira-Maia, Elene C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Synthesis and characterization of a tetracycline–platinum (II) complex active against resistant bacteria</title><author>Chartone-Souza, Edmar ; Loyola, Thaís L. ; Bucciarelli-Rodriguez, Mônica ; Menezes, Maria Ã. de B.C. ; Rey, Nicolás A. ; Pereira-Maia, Elene C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-386b14c8fbf7fc207a82a61c1f5d92228a121dcf245bad89ec9547d7da765baf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antimicrobial activity</topic><topic>Bacterial resistance</topic><topic>Circular Dichroism</topic><topic>Escherichia coli - drug effects</topic><topic>Organoplatinum Compounds - chemical synthesis</topic><topic>Organoplatinum Compounds - chemistry</topic><topic>Organoplatinum Compounds - pharmacology</topic><topic>Synthesis</topic><topic>Tetracycline Resistance</topic><topic>Tetracyclines - chemical synthesis</topic><topic>Tetracyclines - chemistry</topic><topic>Tetracyclines - pharmacology</topic><topic>Tetracycline–platinum complex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chartone-Souza, Edmar</creatorcontrib><creatorcontrib>Loyola, Thaís L.</creatorcontrib><creatorcontrib>Bucciarelli-Rodriguez, Mônica</creatorcontrib><creatorcontrib>Menezes, Maria Ã. de B.C.</creatorcontrib><creatorcontrib>Rey, Nicolás A.</creatorcontrib><creatorcontrib>Pereira-Maia, Elene C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chartone-Souza, Edmar</au><au>Loyola, Thaís L.</au><au>Bucciarelli-Rodriguez, Mônica</au><au>Menezes, Maria Ã. de B.C.</au><au>Rey, Nicolás A.</au><au>Pereira-Maia, Elene C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and characterization of a tetracycline–platinum (II) complex active against resistant bacteria</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>99</volume><issue>5</issue><spage>1001</spage><epage>1008</epage><pages>1001-1008</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>A tetracycline–platinum(II) complex, [PtCl
2(C
22H
24N
2O
8)], was synthesized and characterized by elemental analysis, conductivity and thermogravimetric analyses, and infrared spectroscopy. The interaction of tetracycline (Tc) with platinum(II) ions was also studied in aqueous solution by
1H NMR and circular dichroism spectroscopies. Tetracycline forms a 1:1 complex with platinum via the oxygen of the hydroxyl group at the A ring and that of the amide group. The complex is as efficient as tetracycline in inhibiting the growth of two
Escherichia coli sensitive bacterial strains and six times more potent against
E. coli HB101/pBR322, a bacterial strain resistant to tetracycline. This finding is very important because the use of tetracycline to treat bacterial infections has declined due to the emergence of resistant organisms.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15833322</pmid><doi>10.1016/j.jinorgbio.2005.01.004</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0162-0134 |
| ispartof | Journal of inorganic biochemistry, 2005-05, Vol.99 (5), p.1001-1008 |
| issn | 0162-0134 1873-3344 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimicrobial activity Bacterial resistance Circular Dichroism Escherichia coli - drug effects Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Synthesis Tetracycline Resistance Tetracyclines - chemical synthesis Tetracyclines - chemistry Tetracyclines - pharmacology Tetracycline–platinum complex |
| title | Synthesis and characterization of a tetracycline–platinum (II) complex active against resistant bacteria |
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