A comprehensive classification system for lipids

Lipids are produced, transported, and recognized by the concerted actions of numerous enzymes, binding proteins, and receptors. A comprehensive analysis of lipid molecules, "lipidomics," in the context of genomics and proteomics is crucial to understanding cellular physiology and pathology...

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Bibliographic Details
Published in:Journal of lipid research 2005-05, Vol.46 (5), p.839-861
Main Authors: Fahy, Eoin, Subramaniam, Shankar, Brown, H Alex, Glass, Christopher K, Merrill, Jr, Alfred H, Murphy, Robert C, Raetz, Christian R H, Russell, David W, Seyama, Yousuke, Shaw, Walter, Shimizu, Takao, Spener, Friedrich, van Meer, Gerrit, VanNieuwenhze, Michael S, White, Stephen H, Witztum, Joseph L, Dennis, Edward A
Format: Article
Language:English
Subjects:
Database Management Systems
Lipids - chemistry
Lipids - classification
Molecular Structure
Terminology as Topic
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Summary:Lipids are produced, transported, and recognized by the concerted actions of numerous enzymes, binding proteins, and receptors. A comprehensive analysis of lipid molecules, "lipidomics," in the context of genomics and proteomics is crucial to understanding cellular physiology and pathology; consequently, lipid biology has become a major research target of the postgenomic revolution and systems biology. To facilitate international communication about lipids, a comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by our lipid community. As an initial step in this development, we divide lipids into eight categories (fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, sterol lipids, prenol lipids, saccharolipids, and polyketides) containing distinct classes and subclasses of molecules, devise a common manner of representing the chemical structures of individual lipids and their derivatives, and provide a 12 digit identifier for each unique lipid molecule. The lipid classification scheme is chemically based and driven by the distinct hydrophobic and hydrophilic elements that compose the lipid. This structured vocabulary will facilitate the systematization of lipid biology and enable the cataloging of lipids and their properties in a way that is compatible with other macromolecular databases.
ISSN:0022-2275
DOI:10.1194/jlr.E400004-JLR200