Field-cycled PEDRI imaging of free radicals with detection at 450 mT

This paper describes the design, construction and use of a field-cycled proton–electron double-resonance imaging (FC-PEDRI) system for the detection and imaging of free radicals. The unique feature of this imager is its use of a 450-mT detection magnetic field in order to achieve good image quality...

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Bibliographic Details
Published in:Magnetic resonance imaging 2005-02, Vol.23 (2), p.175-181
Main Authors: Lurie, David J., Davies, Gareth R., Foster, Margaret A., Hutchison, James M.S.
Format: Article
Language:English
Subjects:
Animals
Electron Spin Resonance Spectroscopy - instrumentation
Field cycling
Free radical
Free Radicals
Magnetic Resonance Imaging - instrumentation
Magnetic Resonance Spectroscopy - instrumentation
Magnetics - instrumentation
Male
Overhauser imaging
PEDRI
Phantoms, Imaging
Protons
Rats
Rats, Sprague-Dawley
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Summary:This paper describes the design, construction and use of a field-cycled proton–electron double-resonance imaging (FC-PEDRI) system for the detection and imaging of free radicals. The unique feature of this imager is its use of a 450-mT detection magnetic field in order to achieve good image quality and sensitivity. The detection magnetic field is provided by a superconducting magnet, giving high stability and homogeneity. Field cycling is implemented by switching on and off the current in an internal, coaxial, resistive secondary magnet that partially cancels the superconducting magnet's field at the sample; the secondary magnet is actively shielded to avoid eddy currents. EPR irradiation takes place at ∼5 mT, following which the field is switched to 450 mT in 40 ms for NMR signal detection. Full details of the imager's subsystems are given, and experiments to image the distribution of stable free radical contrast agents in phantoms and in anesthetized rats are described.
ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2004.11.051