Gender differences in pharmacokinetics of oral warfarin in rats

Gender different pharmacokinetics of warfarin were investigated after oral administration at a dose of 2 mg/kg to male and female rats. The concentrations of warfarin in rat plasma were analysed by the HPLC method. Noncompartmental analysis was used for the calculation of the total area under the pl...

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Bibliographic Details
Published in:Biopharmaceutics & drug disposition 2005-05, Vol.26 (4), p.147-150
Main Authors: Zhu, Xuan, Shin, Wan G.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anticoagulants - administration & dosage
Anticoagulants - blood
Anticoagulants - pharmacokinetics
Area Under Curve
Chromatography, High Pressure Liquid
CYP isozymes
Female
gender difference
Male
Metabolic Clearance Rate
pharmacokinetics
Rats
Rats, Sprague-Dawley
Sex Factors
warfarin
Warfarin - administration & dosage
Warfarin - blood
Warfarin - pharmacokinetics
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Summary:Gender different pharmacokinetics of warfarin were investigated after oral administration at a dose of 2 mg/kg to male and female rats. The concentrations of warfarin in rat plasma were analysed by the HPLC method. Noncompartmental analysis was used for the calculation of the total area under the plasma concentration–time curve from time zero to time infinity (AUC) and terminal half‐life of warfarin. After oral administration of warfarin to female rats, the AUC was significantly greater (345 compared with 180 µg h/ml) than that in male rats. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0142-2782
1099-081X
DOI:10.1002/bdd.442