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Gender differences in pharmacokinetics of oral warfarin in rats
Gender different pharmacokinetics of warfarin were investigated after oral administration at a dose of 2 mg/kg to male and female rats. The concentrations of warfarin in rat plasma were analysed by the HPLC method. Noncompartmental analysis was used for the calculation of the total area under the pl...
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| Published in: | Biopharmaceutics & drug disposition 2005-05, Vol.26 (4), p.147-150 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| container_end_page | 150 |
| container_issue | 4 |
| container_start_page | 147 |
| container_title | Biopharmaceutics & drug disposition |
| container_volume | 26 |
| creator | Zhu, Xuan Shin, Wan G. |
| description | Gender different pharmacokinetics of warfarin were investigated after oral administration at a dose of 2 mg/kg to male and female rats. The concentrations of warfarin in rat plasma were analysed by the HPLC method. Noncompartmental analysis was used for the calculation of the total area under the plasma concentration–time curve from time zero to time infinity (AUC) and terminal half‐life of warfarin. After oral administration of warfarin to female rats, the AUC was significantly greater (345 compared with 180 µg h/ml) than that in male rats. Copyright © 2005 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/bdd.442 |
| format | article |
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The concentrations of warfarin in rat plasma were analysed by the HPLC method. Noncompartmental analysis was used for the calculation of the total area under the plasma concentration–time curve from time zero to time infinity (AUC) and terminal half‐life of warfarin. After oral administration of warfarin to female rats, the AUC was significantly greater (345 compared with 180 µg h/ml) than that in male rats. 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Copyright © 2005 John Wiley & Sons, Ltd.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Anticoagulants - administration & dosage</subject><subject>Anticoagulants - blood</subject><subject>Anticoagulants - pharmacokinetics</subject><subject>Area Under Curve</subject><subject>Chromatography, High Pressure Liquid</subject><subject>CYP isozymes</subject><subject>Female</subject><subject>gender difference</subject><subject>Male</subject><subject>Metabolic Clearance Rate</subject><subject>pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sex Factors</subject><subject>warfarin</subject><subject>Warfarin - administration & dosage</subject><subject>Warfarin - blood</subject><subject>Warfarin - pharmacokinetics</subject><issn>0142-2782</issn><issn>1099-081X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpFkFtLAzEQhYMotlbxH8g--SJbM0k22TyJtt6g4IuCbyHNTnB1byYtpf_eSCvCwIGZj-GcQ8g50ClQyq6XVTUVgh2QMVCtc1rC-yEZUxAsZ6pkI3IS4yelVALAMRlBoZQUWo_JzSN2FYasqr3HgJ3DmNVdNnzY0FrXf9UdrmoXs95nfbBNtrHB25CINMGu4ik58raJeLbXCXl7uH-dPeWLl8fn2e0iH0AVyYSQuuKlZc56jo4rtLAsOJMOqEwbhORMoOZCeCGVdhZKzh13gikGXPMJudz9HUL_vca4Mm0dHTaN7bBfRyOVKmhKlMCLPbhetliZIdStDVvzFzkBVztgUze4_b9T89ukSU2a1KS5m8-T8B_dm2N4</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Zhu, Xuan</creator><creator>Shin, Wan G.</creator><general>John Wiley & Sons, Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200505</creationdate><title>Gender differences in pharmacokinetics of oral warfarin in rats</title><author>Zhu, Xuan ; Shin, Wan G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1752-2469d38a2caf3ec37ea1b5326c106f3ee16114e9344f4679ca1833c3c42721393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Anticoagulants - administration & dosage</topic><topic>Anticoagulants - blood</topic><topic>Anticoagulants - pharmacokinetics</topic><topic>Area Under Curve</topic><topic>Chromatography, High Pressure Liquid</topic><topic>CYP isozymes</topic><topic>Female</topic><topic>gender difference</topic><topic>Male</topic><topic>Metabolic Clearance Rate</topic><topic>pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sex Factors</topic><topic>warfarin</topic><topic>Warfarin - administration & dosage</topic><topic>Warfarin - blood</topic><topic>Warfarin - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Xuan</creatorcontrib><creatorcontrib>Shin, Wan G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biopharmaceutics & drug disposition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Xuan</au><au>Shin, Wan G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender differences in pharmacokinetics of oral warfarin in rats</atitle><jtitle>Biopharmaceutics & drug disposition</jtitle><addtitle>Biopharm Drug Dispos</addtitle><date>2005-05</date><risdate>2005</risdate><volume>26</volume><issue>4</issue><spage>147</spage><epage>150</epage><pages>147-150</pages><issn>0142-2782</issn><eissn>1099-081X</eissn><abstract>Gender different pharmacokinetics of warfarin were investigated after oral administration at a dose of 2 mg/kg to male and female rats. 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| fulltext | fulltext |
| identifier | ISSN: 0142-2782 |
| ispartof | Biopharmaceutics & drug disposition, 2005-05, Vol.26 (4), p.147-150 |
| issn | 0142-2782 1099-081X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67750499 |
| source | Wiley |
| subjects | Administration, Oral Animals Anticoagulants - administration & dosage Anticoagulants - blood Anticoagulants - pharmacokinetics Area Under Curve Chromatography, High Pressure Liquid CYP isozymes Female gender difference Male Metabolic Clearance Rate pharmacokinetics Rats Rats, Sprague-Dawley Sex Factors warfarin Warfarin - administration & dosage Warfarin - blood Warfarin - pharmacokinetics |
| title | Gender differences in pharmacokinetics of oral warfarin in rats |
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