New pyrazolo[1′,5′:1,6]pyrimido[4,5- d]pyridazin-4(3 H)-ones as potent and selective PDE5 inhibitors

A series of potent PDE5 inhibitors with high selectivity versus PDE6 was identified. A series of potent PDE5 inhibitors with high selectivity versus PDE6 isoenzymes was identified.

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2005-05, Vol.15 (9), p.2381-2384
Main Authors: Feixas, Joan, Giovannoni, Maria Paola, Vergelli, Claudia, Gavaldà, Amadeu, Cesari, Nicoletta, Graziano, Alessia, Piaz, Vittorio Dal
Format: Article
Language:English
Subjects:
3',5'-Cyclic-GMP Phosphodiesterases
Animals
Biological and medical sciences
Blood Platelets - enzymology
Cattle
Cyclic Nucleotide Phosphodiesterases, Type 5
Cyclic Nucleotide Phosphodiesterases, Type 6
Medical sciences
Miscellaneous
Molecular Structure
Pharmacology. Drug treatments
Phosphodiesterase Inhibitors - chemical synthesis
Phosphodiesterase Inhibitors - pharmacology
Phosphoric Diester Hydrolases - blood
Phosphoric Diester Hydrolases - metabolism
Pyrazoles - chemical synthesis
Pyrazoles - pharmacology
Pyridazines - chemical synthesis
Pyridazines - pharmacology
Retina - enzymology
Sensitivity and Specificity
Structure-Activity Relationship
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of potent PDE5 inhibitors with high selectivity versus PDE6 was identified. A series of potent PDE5 inhibitors with high selectivity versus PDE6 isoenzymes was identified.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.02.090