Effects of therapeutic magnetic stimulation on acute muscle atrophy in rats after hindlimb suspension

In most subjects with spinal cord injury, the spinal neurons below the level of injury are spared. Therefore, it is conceivable that the skeletal muscles innervated by these spinal nerves can be activated by applying therapeutic magnetic stimulation along the dorsal spine. The purpose of this study...

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Bibliographic Details
Published in:Biomedical Research 2006, Vol.27(1), pp.23-27
Main Authors: SHIMADA, Yoichi, SAKURABA, Tsutomu, MATSUNAGA, Toshiki, MISAWA, Akiko, KAWATANI, Masahito, ITOI, Eiji
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Evaluation Studies as Topic
Hindlimb Suspension
Magnetics - therapeutic use
Male
Muscle, Skeletal - cytology
Muscle, Skeletal - surgery
Muscular Atrophy - etiology
Muscular Atrophy - prevention & control
Random Allocation
Rats
Rats, Wistar
Sciatic Nerve - physiology
Time Factors
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Summary:In most subjects with spinal cord injury, the spinal neurons below the level of injury are spared. Therefore, it is conceivable that the skeletal muscles innervated by these spinal nerves can be activated by applying therapeutic magnetic stimulation along the dorsal spine. The purpose of this study was to evaluate the ability of magnetic stimulation to prevent acute muscle atrophy in rats after hindlimb suspension. Forty adult male Wistar rats were randomly assigned to stimulated and non-stimulated (control) groups. Their hindlimbs were unweighted using a suspension method, causing muscle atrophy. In the stimulation group, magnetic stimulation (20 Hz, 60 min per day) was applied to the sciatic nerve for 10 days. After the stimulation period, the tibialis anterior (TA) and extensor digitorum longus (EDL) were surgically removed and histologically measured. The lesser diameters of type 1, 2A, and 2B muscle fibers were significantly greater in the stimulated group than in the non-stimulated group for both the TA and EDL (p < 0.05). The mean difference in lesser fiber diameter was 20% (range, 14%-27%). These results suggest that therapeutic magnetic stimulation is an effective method of preventing muscle atrophy.
ISSN:0388-6107
1880-313X
DOI:10.2220/biomedres.27.23