Anti-Müllerian hormone and folliculogenesis

This paper reviews the role of anti-Müllerian hormone, a member of the TGFβ family signaling through a BMP-like pathway, in the ovary. In vivo and in vitro studies showed that AMH has an inhibitory effect on primordial follicle recruitment and it decreases the sensitivity of follicles for the FSH-de...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2005-04, Vol.234 (1), p.81-86
Main Authors: Visser, Jenny A., Themmen, Axel P.N.
Format: Article
Language:English
Subjects:
Animals
Anti-Mullerian Hormone
Anti-Müllerian hormone
Biological Factors
Female
Fertility
Follicle Stimulating Hormone - metabolism
Folliculogenesis
Glycoproteins - physiology
Humans
Mice
Ovarian Follicle - growth & development
Ovarian Follicle - metabolism
Ovarian reserve
Signal Transduction
Signaling
Testicular Hormones - physiology
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Summary:This paper reviews the role of anti-Müllerian hormone, a member of the TGFβ family signaling through a BMP-like pathway, in the ovary. In vivo and in vitro studies showed that AMH has an inhibitory effect on primordial follicle recruitment and it decreases the sensitivity of follicles for the FSH-dependent selection for dominance. Besides its functional role in the ovary, AMH serum level serves as an excellent candidate marker of ovarian reserve.
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2004.09.008