Intracellular signaling following myocardial stretch: an autocrine/paracrine loop

The stretch of adult papillary muscle elicits a chain of autocrine/paracrine events in which the Na +/H + exchanger (NHE-1) activation is the central step. This activation is induced by a sequential angiotensin II–endothelin (Ang II–ET) release and results in an increase in intracellular Na + (Na +...

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Bibliographic Details
Published in:Regulatory peptides 2005-06, Vol.128 (3), p.211-220
Main Authors: Cingolani, Horacio E., Pérez, Néstor G., Aiello, Ernesto A., Camilión de Hurtado, María C.
Format: Article
Language:English
Subjects:
Angiotensin II
Angiotensin II - physiology
Animals
Biological and medical sciences
Endothelin
Endothelins - physiology
Fundamental and applied biological sciences. Psychology
Heart - physiology
Humans
Hydrogen-Ion Concentration
Myocardial Contraction - drug effects
Myocardial Contraction - physiology
Na +/Ca 2+ exchanger
Na +/H + exchanger
Papillary Muscles - physiology
Signal Transduction - physiology
Sodium - pharmacology
Vertebrates: endocrinology
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Summary:The stretch of adult papillary muscle elicits a chain of autocrine/paracrine events in which the Na +/H + exchanger (NHE-1) activation is the central step. This activation is induced by a sequential angiotensin II–endothelin (Ang II–ET) release and results in an increase in intracellular Na + (Na + i) without significant changes in intracellular pH. The increase in Na + i negatively shifts the reverse potential of the Na +/Ca 2+ exchanger (NCX) thus inducing cell Ca 2+ influx that augments myocardial contractility. This increase in force represents the mechanical counterpart of the autocrine/paracrine mechanism triggered by stretch and has been called the slow force response (SFR) to stretch.
ISSN:0167-0115
1873-1686
DOI:10.1016/j.regpep.2004.12.011