Study of undifferentiated spondyloarthropathy among first-degree relatives of ankylosing spondylitis probands

Objective. To estimate in a Chinese population the prevalence of undifferentiated spondyloarthropathy (USpA) among first-degree relatives (FDRs) of ankylosing spondylitis (AS) probands, and to compare the clinical features of familial USpA with those of sporadic USpA. Methods. The FDRs of two separa...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2005-05, Vol.44 (5), p.662-665
Main Authors: Chou, C. T., Lin, K. C., Wei, J. C. C., Tsai, W. C., Ho, H. H., Hwang, C. M., Cherng, J. M., Hsu, C. M., Yu, D. T. Y.
Format: Article
Language:English
Subjects:
Adult
Ankylosing spondylitis
Biological and medical sciences
China - epidemiology
Cohort Studies
Diseases of the osteoarticular system
Female
First-degree relatives
Genetic Predisposition to Disease
HLA B27
HLA-B27 Antigen - analysis
Humans
Inflammatory joint diseases
Male
Medical sciences
Middle Aged
Prevalence
Spondylarthropathies - ethnology
Spondylarthropathies - genetics
Spondylitis, Ankylosing - ethnology
Spondylitis, Ankylosing - genetics
Undifferentiated spondyloarthropathy
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Summary:Objective. To estimate in a Chinese population the prevalence of undifferentiated spondyloarthropathy (USpA) among first-degree relatives (FDRs) of ankylosing spondylitis (AS) probands, and to compare the clinical features of familial USpA with those of sporadic USpA. Methods. The FDRs of two separate cohorts of consecutive AS probands were evaluated for the prevalence of USpA, using the Modified New York criteria and the European Spondylitis Study Group criteria for AS and SpA, respectively. Sporadic USpA and FDRs of non-SpA rheumatic patient probands served as separate controls. Results. Among the 301 FDRs of 102 AS probands, 7.0% were USpA. This was 1000 times higher than the 147 FDRs of 40 non-SpA probands (P = 0.00230). Within the AS families, USpA was less male-dominated than AS (33.3 vs 72.5%) (P = 0.006). The only feature distinguishing familial from sporadic USpA was that the percentages of HLA B27 were 100 and 50%, respectively (P
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keh577