Immunohistochemical demonstration of connexin-related epithelization defects in a lamb caused by (erythro)keratodermia variabilis

The distribution of four important connexins (Cx 26, 30, 31, 43) in the skin of a neonatal lamb with (erythro)keratodermia (EKV) was demonstrated using immunohistochemistry, including a very sensitive visualization system. The reaction staining for Cx 26, 30 and 31 was negative to weak in all skin s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of veterinary medicine. Series A 2005-04, Vol.52 (3), p.153-156
Main Authors: Meyer, W, Wehrend, A, Schnapper, A, Bostedt, H
Format: Article
Language:English
Subjects:
(erythro)keratodermia variabilis
Animals
Animals, Newborn
Antibodies - analysis
congenital abnormalities
connexins
Connexins - analysis
Dermatitis, Exfoliative - genetics
Dermatitis, Exfoliative - pathology
Dermatitis, Exfoliative - veterinary
epidermis (animal)
epithelial cells
Erythema - genetics
Erythema - pathology
Erythema - veterinary
Fatal Outcome
Female
Genes, Recessive
immunohistochemistry
Immunohistochemistry - veterinary
Immunology
Keratosis - genetics
Keratosis - pathology
Keratosis - veterinary
lambs
Medical disorders
Sheep
sheep diseases
Sheep Diseases - genetics
Sheep Diseases - pathology
Skin
Skin - cytology
Skin - pathology
skin diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The distribution of four important connexins (Cx 26, 30, 31, 43) in the skin of a neonatal lamb with (erythro)keratodermia (EKV) was demonstrated using immunohistochemistry, including a very sensitive visualization system. The reaction staining for Cx 26, 30 and 31 was negative to weak in all skin structures, and only Cx 43 displayed weak to moderate positive reactions, although not uniformly distributed throughout the important systems (e.g. epidermis, hair follicle sheaths). Thus, the study proves for the first time that connexin defects are associated with the development of EKV in domesticated mammals, as they are in humans.
ISSN:0931-184X
1865-1674
1439-0442
1865-1682
DOI:10.1111/j.1439-0442.2005.00699.x