Prognostic significance of plasma osteopontin levels in patients with chronic stable angina

Aims Levels of the secreted glycophosphoprotein osteopontin (OPN) have been associated with the presence and extent of coronary artery disease (CAD). The present study assessed the relationship between plasma OPN concentrations and prognosis in patients with chronic stable angina (CSA). Methods and...

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Published in:European heart journal 2006-04, Vol.27 (7), p.802-807
Main Authors: Minoretti, Piercarlo, Falcone, Colomba, Calcagnino, Margherita, Emanuele, Enzo, Buzzi, Maria P., Coen, Enrico, Geroldi, Diego
Format: Article
Language:English
Subjects:
Angina Pectoris - blood
Angina Pectoris - mortality
Biological and medical sciences
Cardiology. Vascular system
Chronic Disease
Coronary Artery Disease - blood
Coronary heart disease
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Osteopontin
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Risk stratification
Sialoglycoproteins - blood
Stable angina
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Summary:Aims Levels of the secreted glycophosphoprotein osteopontin (OPN) have been associated with the presence and extent of coronary artery disease (CAD). The present study assessed the relationship between plasma OPN concentrations and prognosis in patients with chronic stable angina (CSA). Methods and results OPN was measured in baseline plasma samples from 799 patients with stable angina pectoris and angiographically documented CAD. Participants were prospectively followed-up for a median of 2.7 years (maximum 4.1 years). The primary study endpoint was the composite of non-fatal myocardial infarction and death from cardiovascular causes. In the univariate Cox proportional hazard analysis, the log-transformed OPN level [hazard ratio (HR) 1.79, 95% CI 1.35–2.36, P
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehi730