Complexity of Plasmodium falciparum Infections and Antimalarial Drug Efficacy at 7 Sites in Uganda

Malaria infections in Africa frequently include multiple parasite strains. We examined the relationship between the number of infecting Plasmodium falciparum strains and the responses to 3 different combination therapies in 3072 patients with uncomplicated malaria at 7 sites in Uganda. Patients infe...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2006-04, Vol.193 (8), p.1160-1163
Main Authors: Lee, Sulggi A., Yeka, Adoke, Nsobya, Samuel L., Dokomajilar, Christian, Rosenthal, Philip J., Talisuna, Ambrose, Dorsey, Grant
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Animals
Antimalarials
Antimalarials - administration & dosage
Antimalarials - pharmacology
Child
Child, Preschool
Clinical trials
Drug Therapy, Combination
Health outcomes
Humans
Infant
Infections
Malaria
Malaria, Falciparum - drug therapy
Medical treatment failures
Middle Aged
Odds Ratio
Parasite hosts
Parasites
Plasmodium falciparum
Plasmodium falciparum - classification
Plasmodium falciparum - drug effects
Plasmodium falciparum - pathogenicity
Pretreatment
Relapse
Treatment Outcome
Uganda
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Malaria infections in Africa frequently include multiple parasite strains. We examined the relationship between the number of infecting Plasmodium falciparum strains and the responses to 3 different combination therapies in 3072 patients with uncomplicated malaria at 7 sites in Uganda. Patients infected with ⩾3 strains had almost 3 times the odds of treatment failure (odds ratio, 2.93 [95% confidence interval, 2.51–3.43]; P
ISSN:0022-1899
1537-6613
DOI:10.1086/501473