Growth Factor Withdrawal and Apoptosis: The Middle Game

In this issue of Molecular Cell, Maurer et al. (2006) detail molecular events that trigger apoptosis following growth factor withdrawal, linking irreversible mitochondrial permeabilization to activation of GSK-3 and subsequent phosphorylation, ubiquitinylation, and degradation of the antiapoptotic B...

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Bibliographic Details
Published in:Molecular cell 2006-03, Vol.21 (6), p.728-730
Main Author: Letai, Anthony
Format: Article
Language:English
Subjects:
Apoptosis
Cell Membrane - metabolism
Glycogen Synthase Kinase 3 - physiology
Growth Substances - physiology
Interleukin-3 - pharmacology
Mitochondria - metabolism
Models, Biological
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Proteins - metabolism
Phosphatidylinositol 3-Kinases - physiology
Phosphorylation
Protein Processing, Post-Translational
Proto-Oncogene Proteins c-akt - physiology
Proto-Oncogene Proteins c-bcl-2 - metabolism
Signal Transduction
Ubiquitin - metabolism
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Summary:In this issue of Molecular Cell, Maurer et al. (2006) detail molecular events that trigger apoptosis following growth factor withdrawal, linking irreversible mitochondrial permeabilization to activation of GSK-3 and subsequent phosphorylation, ubiquitinylation, and degradation of the antiapoptotic BCL-2 family member MCL-1.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2006.03.005