Exposed and concealed antigens as vaccine targets for controlling ticks and tick‐borne diseases

SUMMARY Tick vaccines derived from Bm86, a midgut membrane‐bound protein of the cattle tick, Boophilus microplus, are currently the only commercially available ectoparasite vaccines. Despite its introduction to the market in 1994, and the recognized need for alternatives to chemical pesticides, prog...

Full description

Saved in:
Bibliographic Details
Published in:Parasite immunology 2006-04, Vol.28 (4), p.155-163
Main Authors: NUTTALL, P. A., TRIMNELL, A. R., KAZIMIROVA, M., LABUDA, M.
Format: Article
Language:English
Subjects:
Animals
Antigens - immunology
Arachnid Vectors - immunology
Boophilus microplus
concealed antigens
Disease Transmission, Infectious - prevention & control
dual acting tick vaccine
exposed antigens
Humans
Ixodidae
Life Cycle Stages
Membrane Glycoproteins - immunology
Recombinant Proteins - immunology
Saliva - immunology
Tick Control - methods
Tick Infestations - prevention & control
tick vaccines
Tick-Borne Diseases - prevention & control
Ticks - chemistry
Ticks - growth & development
Ticks - immunology
Vaccines - immunology
Vaccines, DNA
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:SUMMARY Tick vaccines derived from Bm86, a midgut membrane‐bound protein of the cattle tick, Boophilus microplus, are currently the only commercially available ectoparasite vaccines. Despite its introduction to the market in 1994, and the recognized need for alternatives to chemical pesticides, progress in developing effective antitick vaccines (and ectoparasite vaccines in general) is slow. The primary rate‐limiting step is the identification of suitable antigenic targets for vaccine development. Two sources of candidate vaccine antigens have been identified: ‘exposed’ antigens that are secreted in tick saliva during attachment and feeding on a host and ‘concealed’ antigens that are normally hidden from the host. Recently, a third group of antigens has been distinguished that combines the properties of both exposed and concealed antigens. This latter group offers the prospect of a broad‐spectrum vaccine effective against both adults and immature stages of a wide variety of tick species. It also shows transmission‐blocking and protective activity against a tick‐borne pathogen. With the proliferation of molecular techniques and their application to vaccine development, there are high hopes for new and effective antitick vaccines that also control tick‐borne diseases.
ISSN:0141-9838
1365-3024
DOI:10.1111/j.1365-3024.2006.00806.x