Potential of KM+ lectin in immunization against Leishmania amazonensis infection

In the present study we evaluated Canavalia brasiliensis (ConBr), Pisum arvense (PAA) and Artocarpus integrifolia (KM+) lectins as immunostimulatory molecules in vaccination against Leishmania amazonensis infection. Although they induced IFN-γ production, the combination of the lectins with SLA anti...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2006-04, Vol.24 (15), p.3001-3008
Main Authors: Teixeira, Clarissa R., Cavassani, Karen A., Gomes, Regis B., Teixeira, Maria Jania, Roque-Barreira, Maria-Cristina, Cavada, Benildo S., Silva, João Santana da, Barral, Aldina, Barral-Netto, Manoel
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - pharmacology
Animal Structures - parasitology
Animals
Antigens, Protozoan - administration & dosage
Antigens, Protozoan - immunology
Applied microbiology
Artocarpus
Artocarpus integrifolia
Biological and medical sciences
Bone-marrow-derived dendritic cells (BMDC)
Canavalia
Dendritic Cells - chemistry
Dendritic Cells - immunology
Female
Fundamental and applied biological sciences. Psychology
Histocompatibility Antigens Class II - analysis
Interferon-gamma - biosynthesis
Interleukin-12 - biosynthesis
Lectin
Leishmania
Leishmania - immunology
Leishmania amazonensis
Leishmaniasis - immunology
Leishmaniasis - pathology
Lymphocytes - immunology
Male
Mice
Mice, Inbred BALB C
Microbiology
Pisum
Pisum arvense
Plant Lectins - administration & dosage
Plant Lectins - pharmacology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present study we evaluated Canavalia brasiliensis (ConBr), Pisum arvense (PAA) and Artocarpus integrifolia (KM+) lectins as immunostimulatory molecules in vaccination against Leishmania amazonensis infection. Although they induced IFN-γ production, the combination of the lectins with SLA antigen did not lead to lesion reduction. However, parasite load was largely reduced in mice immunized with KM+ lectin and SLA. KM+ induced a smaller inflammatory reaction in the air pouch model and was able to inhibit differentiation of dendritic cells (BMDC), but to induce maturation by enhancing the expression of MHC II, CD80 and CD86. These observations indicate the modulatory role of plant lectins in leishmaniasis vaccination may be related to their action on the initial innate response.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.11.067