Type I IFN Receptor Signals Directly Stimulate Local B Cells Early following Influenza Virus Infection

Rapidly developing Ab responses to influenza virus provide immune protection even during a primary infection. How these early B cell responses are regulated is incompletely understood. In this study, we show that the first direct stimulatory signal for local respiratory tract B cells during influenz...

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Bibliographic Details
Published in:Journal of Immunology 2006-04, Vol.176 (7), p.4343-4351
Main Authors: Coro, Elizabeth S, Chang, W. L. William, Baumgarth, Nicole
Format: Article
Language:English
Subjects:
Animals
Antibodies - immunology
B-Lymphocytes - cytology
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Cell Proliferation
Female
Gene Expression Regulation, Viral
Influenza virus
Interferons - pharmacology
Lymph Nodes - drug effects
Lymph Nodes - immunology
Lymphocyte Activation
Membrane Proteins - deficiency
Membrane Proteins - metabolism
Mice
Orthomyxoviridae - immunology
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - metabolism
Orthomyxoviridae Infections - virology
Receptor, Interferon alpha-beta
Receptors, Interferon - deficiency
Receptors, Interferon - metabolism
Signal Transduction
Time Factors
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Summary:Rapidly developing Ab responses to influenza virus provide immune protection even during a primary infection. How these early B cell responses are regulated is incompletely understood. In this study, we show that the first direct stimulatory signal for local respiratory tract B cells during influenza virus infection is provided through the type I IFNR. IFNR-mediated signals were responsible for the influenza infection-induced local but not systemic up-regulation of CD69 and CD86 on virtually all lymph node B cells and for induction of a family of IFN-regulated genes within 48 h of infection. These direct IFNR-mediated signals were shown to affect both the magnitude and quality of the local virus-specific Ab response. Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses.
ISSN:0022-1767
1550-6606
1365-2567
DOI:10.4049/jimmunol.176.7.4343