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Glucan and Glutamine Reduce Bacterial Translocation in Rats Subjected to Intestinal Ischemia-Reperfusion

Intestinal ischemia/reperfusion (I/R) may induce bacterial translocation (BT). Glutamine (GLN)-enriched nutrition decreases BT. However, little is known about the effect of glucan (GL) in BT. This study investigated the combined effect of GL/GLN on BT, intestinal damage, and portal blood cytokines i...

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Published in:Journal of investigative surgery 2006, Vol.19 (1), p.39-46
Main Authors: Medeiros, Aldo Cunha, Chacon, Dâmaso Araújo, Sales, Valéria Soraya Farias, Egito, Eryvaldo Sócrates Tabosa, Brandão-Neto, José, Pinheiro, Laíza Araújo Mohana, Carvalho, Mariana Rego
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Language:English
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Summary:Intestinal ischemia/reperfusion (I/R) may induce bacterial translocation (BT). Glutamine (GLN)-enriched nutrition decreases BT. However, little is known about the effect of glucan (GL) in BT. This study investigated the combined effect of GL/GLN on BT, intestinal damage, and portal blood cytokines in animals under I/R. Four groups of 10 rats each were subjected to 60 min of intestinal ischemia and 120 min of reperfusion. The control group (group 1) received only rat food/water, group 2 received glutamine via gavage, group 3 received subcutaneuos soluble (1, 3)-d-glucan, and group 4 received GL + GLN. A sham group (group 5) served as a normal control. Bacterial cultures of ileum, mesenteric lymph nodes (MLN), liver and lung biopsies, histological changes of ileum, and serum cytokines variables were examined after I/R. Data were analyzed by analysis of variance (ANOVA) and the Newman-Keuls test. Results showed that GLN, GL, and GL/GLN significantly reduced BT to MLN, liver, and lung. BT was more attenuated after GL treatment than GLN (P
ISSN:0894-1939
1521-0553
DOI:10.1080/08941930500444453