Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities

• Published in: Bioorganic & medicinal chemistry letters 2006-05, Vol.16 (9), p.2446-2449
• Main Authors: Chattopadhyay, Sunil K., Pal, Anirban, Maulik, Prakas R., Kaur, Tanpreet, Garg, Ankur, Khanuja, Suman Preet S.
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Biological and medical sciences; Cell Line, Tumor; Cell Proliferation - drug effects; Concanavalin A - pharmacology; Crystallography, X-Ray; Cytotoxic; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; General pharmacology; Humans; Immunologic Factors - chemistry; Immunologic Factors - isolation & purification; Immunologic Factors - pharmacology; Immunomodulatory; Lymphocytes - drug effects; Medical sciences; Models, Molecular; Molecular Conformation; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Structure determination; Taxaceae; Taxoid; Taxoids - chemistry; Taxoids - isolation & purification; Taxoids - pharmacology; Taxus - chemistry; Taxus wallichiana; Vinblastine - pharmacology; Vincristine - pharmacology; X-ray analysis
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2006.01.077

From the needles of Taxus wallichiana, a taxoid was isolated, characterized and its cytotoxic and immunomodulatory activities were evaluated. The needles of Taxus wallichiana gave a taxoid 1-hydroxy- 2-deacetoxy-5-decinnamoyl-taxinine j, whose structure has been established by spectroscopic data and confirmed by X-ray crystallography. The taxoid possesses significant cytotoxic and immunomodulatory activity.