Diabetic Cardiomyopathy: The Search for a Unifying Hypothesis

Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and a...

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Bibliographic Details
Published in:Circulation research 2006-03, Vol.98 (5), p.596-605
Main Authors: Poornima, Indu G, Parikh, Pratik, Shannon, Richard P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathies - etiology
Coronary Circulation
Diabetes Complications - etiology
Diabetes Complications - pathology
Diabetes Complications - physiopathology
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 2 - complications
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty Acids, Nonesterified - blood
Fundamental and applied biological sciences. Psychology
Heart
Humans
Hyperglycemia - complications
Hyperinsulinism - complications
Hypertrophy, Left Ventricular - etiology
Insulin Resistance
Medical sciences
Myocarditis. Cardiomyopathies
Phosphatidylinositol 3-Kinases - physiology
Proto-Oncogene Proteins c-akt - physiology
Ventricular Dysfunction, Left - etiology
Vertebrates: cardiovascular system
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Summary:Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and alterations in the coronary microcirculation have all been observed, although not consistently, in diabetic cardiomyopathy and are not fully explained by the cellular effects of hyperglycemia alone. The recent recognition that diabetes involves more than abnormal glucose homeostasis provides important new opportunities to examine and understand the impact of complex metabolic disturbances on cardiac structure and function.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.0000207406.94146.c2