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Posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis in a lung transplant patient
A 58-year-old lung transplant patient developed worsening shortness of breath and indurated erythematous plaques on the lower left leg. A skin biopsy specimen revealed a dense angiocentric and angioinvasive infiltrate in the mid to reticular dermis and panniculus containing large, atypical lymphocyt...
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| Published in: | Journal of the American Academy of Dermatology 2006-04, Vol.54 (4), p.657-663 |
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| cites | cdi_FETCH-LOGICAL-c387t-1b112000d0e1d8a1f6694ee61ddb39bf0458555787ab2ceced60407f404ef3a93 |
| container_end_page | 663 |
| container_issue | 4 |
| container_start_page | 657 |
| container_title | Journal of the American Academy of Dermatology |
| container_volume | 54 |
| creator | Kwon, Eun Ji Katz, Kenneth A. Draft, Karla S. Seykora, John T. Rook, Alain H. Wasik, Mariusz A. Junkins-Hopkins, Jacqueline M. |
| description | A 58-year-old lung transplant patient developed worsening shortness of breath and indurated erythematous plaques on the lower left leg. A skin biopsy specimen revealed a dense angiocentric and angioinvasive infiltrate in the mid to reticular dermis and panniculus containing large, atypical lymphocytes with convoluted nuclei and prominent nucleoli. Immunohistochemical stains showed that the atypical cells were of B-cell origin, and that Epstein-Barr virus was present. Molecular studies demonstrated B-cell clonality. The patient was successfully treated with rituximab. The clinical and pathologic features in this case represent posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis. The case also highlights the importance of clinical and pathologic examination of cutaneous lesions in the evaluation of lymphoproliferative disorders for patients undergoing transplantation. |
| doi_str_mv | 10.1016/j.jaad.2005.11.1066 |
| format | article |
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A skin biopsy specimen revealed a dense angiocentric and angioinvasive infiltrate in the mid to reticular dermis and panniculus containing large, atypical lymphocytes with convoluted nuclei and prominent nucleoli. Immunohistochemical stains showed that the atypical cells were of B-cell origin, and that Epstein-Barr virus was present. Molecular studies demonstrated B-cell clonality. The patient was successfully treated with rituximab. The clinical and pathologic features in this case represent posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis. The case also highlights the importance of clinical and pathologic examination of cutaneous lesions in the evaluation of lymphoproliferative disorders for patients undergoing transplantation.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2005.11.1066</identifier><identifier>PMID: 16546589</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Dermatology ; Epstein-Barr Virus Infections - complications ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lung Diseases - etiology ; Lung Diseases - pathology ; Lung Transplantation - adverse effects ; Lymphomatoid Granulomatosis - etiology ; Lymphomatoid Granulomatosis - pathology ; Lymphoproliferative Disorders - etiology ; Lymphoproliferative Disorders - pathology ; Lymphoproliferative Disorders - virology ; Male ; Medical sciences ; Middle Aged ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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A skin biopsy specimen revealed a dense angiocentric and angioinvasive infiltrate in the mid to reticular dermis and panniculus containing large, atypical lymphocytes with convoluted nuclei and prominent nucleoli. Immunohistochemical stains showed that the atypical cells were of B-cell origin, and that Epstein-Barr virus was present. Molecular studies demonstrated B-cell clonality. The patient was successfully treated with rituximab. The clinical and pathologic features in this case represent posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis. The case also highlights the importance of clinical and pathologic examination of cutaneous lesions in the evaluation of lymphoproliferative disorders for patients undergoing transplantation.</description><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lung Diseases - etiology</subject><subject>Lung Diseases - pathology</subject><subject>Lung Transplantation - adverse effects</subject><subject>Lymphomatoid Granulomatosis - etiology</subject><subject>Lymphomatoid Granulomatosis - pathology</subject><subject>Lymphoproliferative Disorders - etiology</subject><subject>Lymphoproliferative Disorders - pathology</subject><subject>Lymphoproliferative Disorders - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Skin - pathology</subject><subject>Skin Diseases - etiology</subject><subject>Skin Diseases - pathology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kM2OFCEURonROD2jT2Bi2OiuWqgfKBYuzEQdk0l0oWtCwWWGTlVRcqkx_fbSdiW9c0Ug537c7xDyhrM9Z1x8OOwPxrh9zVi357y8CfGM7DhTshKyl8_JjnHFKiXq-opcIx4YY6pt5EtyxUXXiq5XO3L8ETHnZGZcRjNnk0Oc6Xiclse4pDgGD6m8PQF1AcEg0D8hP1IPJq8JkEa_wZPJMTj6UJLW8d8NA9IwU0PHdX6gly_oUgJhzq_IC29GhNfbeUN-ffn88_auuv_-9dvtp_vKNr3MFR84LxWZY8Bdb7gXQrUAgjs3NGrwrO36rutKYTPUFiw4wVomfcta8I1RzQ15f84tfX6vgFlPAS2MZReIK2ohpahFLwrYnEGbImICr5cUJpOOmjN9Mq4P-mRcn4xrzvXJeJl6u8WvwwTuMrMpLsC7DTBozeiLCBvwwknJpGqawn08c1BkPAVIGm3xVAqFBDZrF8N_F_kLOKSjQw</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Kwon, Eun Ji</creator><creator>Katz, Kenneth A.</creator><creator>Draft, Karla S.</creator><creator>Seykora, John T.</creator><creator>Rook, Alain H.</creator><creator>Wasik, Mariusz A.</creator><creator>Junkins-Hopkins, Jacqueline M.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis in a lung transplant patient</title><author>Kwon, Eun Ji ; Katz, Kenneth A. ; Draft, Karla S. ; Seykora, John T. ; Rook, Alain H. ; Wasik, Mariusz A. ; Junkins-Hopkins, Jacqueline M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-1b112000d0e1d8a1f6694ee61ddb39bf0458555787ab2ceced60407f404ef3a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Epstein-Barr Virus Infections - complications</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lung Diseases - etiology</topic><topic>Lung Diseases - pathology</topic><topic>Lung Transplantation - adverse effects</topic><topic>Lymphomatoid Granulomatosis - etiology</topic><topic>Lymphomatoid Granulomatosis - pathology</topic><topic>Lymphoproliferative Disorders - etiology</topic><topic>Lymphoproliferative Disorders - pathology</topic><topic>Lymphoproliferative Disorders - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Skin - pathology</topic><topic>Skin Diseases - etiology</topic><topic>Skin Diseases - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwon, Eun Ji</creatorcontrib><creatorcontrib>Katz, Kenneth A.</creatorcontrib><creatorcontrib>Draft, Karla S.</creatorcontrib><creatorcontrib>Seykora, John T.</creatorcontrib><creatorcontrib>Rook, Alain H.</creatorcontrib><creatorcontrib>Wasik, Mariusz A.</creatorcontrib><creatorcontrib>Junkins-Hopkins, Jacqueline M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwon, Eun Ji</au><au>Katz, Kenneth A.</au><au>Draft, Karla S.</au><au>Seykora, John T.</au><au>Rook, Alain H.</au><au>Wasik, Mariusz A.</au><au>Junkins-Hopkins, Jacqueline M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis in a lung transplant patient</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>54</volume><issue>4</issue><spage>657</spage><epage>663</epage><pages>657-663</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>A 58-year-old lung transplant patient developed worsening shortness of breath and indurated erythematous plaques on the lower left leg. 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| issn | 0190-9622 1097-6787 |
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| source | ScienceDirect Journals |
| subjects | Biological and medical sciences Dermatology Epstein-Barr Virus Infections - complications Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lung Diseases - etiology Lung Diseases - pathology Lung Transplantation - adverse effects Lymphomatoid Granulomatosis - etiology Lymphomatoid Granulomatosis - pathology Lymphoproliferative Disorders - etiology Lymphoproliferative Disorders - pathology Lymphoproliferative Disorders - virology Male Medical sciences Middle Aged Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin - pathology Skin Diseases - etiology Skin Diseases - pathology |
| title | Posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis in a lung transplant patient |
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