Recombinant Salmonella vaccines for biodefence

There is a requirement for vaccines to protect against pathogens that may be misused for bioterrorism or biowarfare purposes. In particular, biodefence vaccines are required that may be used for safe and easy immunisation of populations and that can rapidly induce mucosal immunity to provide protect...

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Bibliographic Details
Published in:Vaccine 2006-04, Vol.24 (15), p.2710-2717
Main Authors: Atkins, Helen S., Morton, Margaret, Griffin, Kate F., Stokes, Margaret G.M., Nataro, James P., Titball, Richard W.
Format: Article
Language:English
Subjects:
Applied microbiology
Attenuated Salmonella
Bacteriology
Biodefence
Biological and medical sciences
Biological Warfare
Bioterrorism
Fundamental and applied biological sciences. Psychology
Humans
Microbiology
Miscellaneous
Salmonella
Salmonella - genetics
Salmonella - immunology
Salmonella vaccine
Salmonella Vaccines - genetics
Salmonella Vaccines - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Synthetic - genetics
Vaccines, Synthetic - immunology
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Summary:There is a requirement for vaccines to protect against pathogens that may be misused for bioterrorism or biowarfare purposes. In particular, biodefence vaccines are required that may be used for safe and easy immunisation of populations and that can rapidly induce mucosal immunity to provide protection at the lung surface against a range of airborne agents. To address this need, recombinant Salmonella vaccines are being developed. In this review, the technologies used, considerations needed, progress made, and future prospects for developing multivalent Salmonella-based vaccines for biodefence are discussed.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.12.046