Diabetes and chronic nitrate therapy as co-determinants of somatic DNA damage in patients with coronary artery disease

Somatic DNA damage has been linked to coronary artery disease (CAD). However, whether genetic instability is linked to CAD per se or to concomitant potentially genotoxic metabolic and pharmacological factors remains still unclear. The aim of this study was to evaluate the determinants of somatic DNA...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2005-04, Vol.83 (4), p.279-286
Main Authors: ANDREASSI, Maria Grazia, BOTTO, Nicoletta, SIMI, Silvana, CASELLA, Marta, MANFREDI, Samantha, LUCARELLI, Marilena, VENNERI, Lucia, BIAGINI, Andrea, PICANO, Eugenio
Format: Article
Language:English
Subjects:
Biological and medical sciences
Coronary Angiography
Coronary Artery Disease - diagnosis
Coronary Artery Disease - genetics
Diabetes Complications - genetics
Diabetes Mellitus, Type 2 - drug therapy
Diabetes. Impaired glucose tolerance
DNA Damage
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
General aspects
Humans
Hyperlipidemias - complications
Hyperlipidemias - genetics
Male
Medical sciences
Micronucleus Tests
Middle Aged
Nitrates - therapeutic use
Regression Analysis
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Summary:Somatic DNA damage has been linked to coronary artery disease (CAD). However, whether genetic instability is linked to CAD per se or to concomitant potentially genotoxic metabolic and pharmacological factors remains still unclear. The aim of this study was to evaluate the determinants of somatic DNA damage in a large population of patients undergoing coronary angiography. A total of 278 in-hospital patients (215 men, age 61.8+/-0.7 years) were studied by using micronucleus assay (MN) in human lymphocytes, which is one of the most commonly used biomarker for somatic DNA damage. Significant CAD (>50% diameter stenosis) was present in 210 patients (179 men, age 62.3+/-0.7 years). Normal coronary arteries were observed in 68 patients (35 men, age 60.2+/-1.7 years). There were no significant differences between patients with and without CAD, but patients with multivessel disease had the highest MN levels (P=0.01). MN frequency was also found significantly higher in presence of type 2 diabetes (P
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-005-0634-8