A practical and green approach towards synthesis of dihydropyrimidinones: Using heteropoly acids as efficient catalysts

One-pot synthesis of dihydropyrimidones catalyzed by heteropoly acids as efficient, inexpensive, easily available and environmentally friendly catalysts. High to excellent yields, short reaction times and compatibility with various functional groups are features of this new procedure. A simple and g...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2006-05, Vol.16 (9), p.2463-2466
Main Authors: Rafiee, Ezzat, Jafari, Hadi
Format: Article
Language:English
Subjects:
Acids - chemistry
Biginelli reaction
Catalysis
Chemistry
Cyclization
Dihydropyrimidinones or thiones (DHPMs)
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Heteropoly acid
Molecular Structure
Multicomponent reactions (MCR)
Organic chemistry
Preparations and properties
Pyrimidinones - chemical synthesis
Pyrimidinones - chemistry
Stereoisomerism
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Summary:One-pot synthesis of dihydropyrimidones catalyzed by heteropoly acids as efficient, inexpensive, easily available and environmentally friendly catalysts. High to excellent yields, short reaction times and compatibility with various functional groups are features of this new procedure. A simple and green chemistry procedure for the synthesis of dihydropyrimidinones using heteropoly acid mediated cyclocondensation reaction is described. This method provides an efficient and much improved modification of the original Biginelli reaction reported in 1893, in terms of high yields, and short reaction times. It has the ability to allow a wide variety of substitutions in all three components.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.01.087