Iso-, Nor-, and Dinor-Spiculoic Acids A, Polyketides from the Marine Sponge Plakortis zyggompha

The new iso-, nor-, and dinor-spiculoic acids A (1, 2, and 3, respectively) with a rare spiculane skeleton were isolated from the marine sponge Plakortis zyggompha, collected in the waters south of Martinique. The structural determination of the compounds was based on 1D and 2D NMR studies and mass...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-04, Vol.68 (4), p.547-549
Main Authors: BERRUé, Fabrice, THOMAS, Olivier P., FERNáNDEZ, Rogelio, AMADE, Philippe
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological and medical sciences
Carboxylic Acids - chemistry
Carboxylic Acids - isolation & purification
Carboxylic Acids - pharmacology
Demospongiae
Drug Screening Assays, Antitumor
General pharmacology
HT29 Cells
Humans
Indans - chemistry
Indans - isolation & purification
Indans - pharmacology
Marine
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plakortis
Plakortis - chemistry
Plakortis zyggompha
Spain
Tumor Cells, Cultured
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Summary:The new iso-, nor-, and dinor-spiculoic acids A (1, 2, and 3, respectively) with a rare spiculane skeleton were isolated from the marine sponge Plakortis zyggompha, collected in the waters south of Martinique. The structural determination of the compounds was based on 1D and 2D NMR studies and mass spectral determinations. Compounds 1 and 2 showed weak cytotoxicity against the two tumor cell lines A549 and HT29.
ISSN:0163-3864
1520-6025
DOI:10.1021/np049602c