Evaluation of four mass spectrometric methods for the gas chromatographic analysis of polychlorinated n-alkanes

The suitability of four mass spectrometric methods for the gas chromatographic analysis of polychlorinated n-alkanes (PCAs, also called chlorinated paraffins) was evaluated and compared using spiked and fish liver samples. Electron ionization tandem mass spectrometry (EI–MS/MS) as well as electron c...

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Bibliographic Details
Published in:Journal of Chromatography A 2005-03, Vol.1067 (1), p.295-301
Main Authors: Zencak, Zdenek, Borgen, Anders, Reth, Margot, Oehme, Michael
Format: Article
Language:English
Subjects:
Alkanes - analysis
Animals
Chlorinated paraffins
Chromatography, Gas - methods
Fishes
Hydrocarbons, Chlorinated - analysis
Intercomparison
Liver - chemistry
Mass spectrometry
Mass Spectrometry - methods
Polychlorinated n-alkanes
Reference Standards
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Summary:The suitability of four mass spectrometric methods for the gas chromatographic analysis of polychlorinated n-alkanes (PCAs, also called chlorinated paraffins) was evaluated and compared using spiked and fish liver samples. Electron ionization tandem mass spectrometry (EI–MS/MS) as well as electron capture negative ionization (ECNI) combined with low and high resolution mass spectrometry and CH 4/CH 2Cl 2-negative ion chemical ionization (NICI) low resolution mass spectrometry were investigated. All methods showed an accuracy of 100% for the ECNI methods. EI–MS/MS and CH 4/CH 2Cl 2-NICI led to errors of maximum 17% and 33%, respectively, independent from the degree of chlorination of the used reference standard.
ISSN:0021-9673
DOI:10.1016/j.chroma.2004.09.098