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Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction
A HPLC and pressurized liquid extraction (PLE) method was developed for simultaneous determination of nine saponins, including notoginsenoside R1, ginsenoside Rg1, Re, Rf, Rb1, Rc, Rb2, Rb3 and Rd in Panax notoginseng. The analysis was performed on C 18 column with water–acetonitrile gradient elutio...
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| Published in: | Journal of pharmaceutical and biomedical analysis 2006-04, Vol.41 (1), p.274-279 |
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| cited_by | cdi_FETCH-LOGICAL-c314t-515ca7a3f20486138a1c5b225d85dbbb9eaf120b4d0dff76c46df57b3394f97f3 |
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| cites | cdi_FETCH-LOGICAL-c314t-515ca7a3f20486138a1c5b225d85dbbb9eaf120b4d0dff76c46df57b3394f97f3 |
| container_end_page | 279 |
| container_issue | 1 |
| container_start_page | 274 |
| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Wan, J.B. Lai, C.M. Li, S.P. Lee, M.Y. Kong, L.Y. Wang, Y.T. |
| description | A HPLC and pressurized liquid extraction (PLE) method was developed for simultaneous determination of nine saponins, including notoginsenoside R1, ginsenoside Rg1, Re, Rf, Rb1, Rc, Rb2, Rb3 and Rd in
Panax notoginseng. The analysis was performed on C
18 column with water–acetonitrile gradient elution and the investigated saponins were authenticated by comparing retention time and mass spectra with their reference compounds. Several methods including PLE, ultrasonication, soxhlet extraction and immersion were used for sample preparation and their extraction efficiency was compared. The results showed that PLE has the highest extraction efficiency and repeatability, which would be valuable on standardization of sample preparation for quality control of Chinese medicines. The developed HPLC and PLE is an effective approach for simultaneously quantitative determination of sapoinins in
P. notoginseng, which could be used for quality control of
P. notoginseng and its preparations. |
| doi_str_mv | 10.1016/j.jpba.2005.10.023 |
| format | article |
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Panax notoginseng. The analysis was performed on C
18 column with water–acetonitrile gradient elution and the investigated saponins were authenticated by comparing retention time and mass spectra with their reference compounds. Several methods including PLE, ultrasonication, soxhlet extraction and immersion were used for sample preparation and their extraction efficiency was compared. The results showed that PLE has the highest extraction efficiency and repeatability, which would be valuable on standardization of sample preparation for quality control of Chinese medicines. The developed HPLC and PLE is an effective approach for simultaneously quantitative determination of sapoinins in
P. notoginseng, which could be used for quality control of
P. notoginseng and its preparations.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2005.10.023</identifier><identifier>PMID: 16316736</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Calibration ; Chemistry, Pharmaceutical - methods ; Chromatography ; Chromatography, High Pressure Liquid - methods ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Ginsenoside ; Ginsenosides - analysis ; Ginsenosides - pharmacology ; Mass Spectrometry ; Medical sciences ; Models, Chemical ; Notoginsenoside ; Panax - metabolism ; Panax notoginseng ; Pharmacology. Drug treatments ; Plant Extracts - analysis ; Plant Extracts - chemistry ; Pressurized liquid extraction ; Saponins - analysis ; Saponins - chemistry ; Spectrometry, Mass, Electrospray Ionization - methods ; Technology, Pharmaceutical - methods ; Time Factors</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2006-04, Vol.41 (1), p.274-279</ispartof><rights>2005 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-515ca7a3f20486138a1c5b225d85dbbb9eaf120b4d0dff76c46df57b3394f97f3</citedby><cites>FETCH-LOGICAL-c314t-515ca7a3f20486138a1c5b225d85dbbb9eaf120b4d0dff76c46df57b3394f97f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17619324$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16316736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wan, J.B.</creatorcontrib><creatorcontrib>Lai, C.M.</creatorcontrib><creatorcontrib>Li, S.P.</creatorcontrib><creatorcontrib>Lee, M.Y.</creatorcontrib><creatorcontrib>Kong, L.Y.</creatorcontrib><creatorcontrib>Wang, Y.T.</creatorcontrib><title>Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>A HPLC and pressurized liquid extraction (PLE) method was developed for simultaneous determination of nine saponins, including notoginsenoside R1, ginsenoside Rg1, Re, Rf, Rb1, Rc, Rb2, Rb3 and Rd in
Panax notoginseng. The analysis was performed on C
18 column with water–acetonitrile gradient elution and the investigated saponins were authenticated by comparing retention time and mass spectra with their reference compounds. Several methods including PLE, ultrasonication, soxhlet extraction and immersion were used for sample preparation and their extraction efficiency was compared. The results showed that PLE has the highest extraction efficiency and repeatability, which would be valuable on standardization of sample preparation for quality control of Chinese medicines. The developed HPLC and PLE is an effective approach for simultaneously quantitative determination of sapoinins in
P. notoginseng, which could be used for quality control of
P. notoginseng and its preparations.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Ginsenoside</subject><subject>Ginsenosides - analysis</subject><subject>Ginsenosides - pharmacology</subject><subject>Mass Spectrometry</subject><subject>Medical sciences</subject><subject>Models, Chemical</subject><subject>Notoginsenoside</subject><subject>Panax - metabolism</subject><subject>Panax notoginseng</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - analysis</subject><subject>Plant Extracts - chemistry</subject><subject>Pressurized liquid extraction</subject><subject>Saponins - analysis</subject><subject>Saponins - chemistry</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Time Factors</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp9kE-L1DAYh4Mo7rj6BTxILnrrmH9NWvAig7rCgAsqeAtp8mbJ0CbdpJXVT2_KDOzNSxJ-PO-PNw9CrynZU0Ll-9P-NA9mzwhpa7AnjD9BO9op3jApfj1FO6I4bRTp2iv0opQTqSDtxXN0RSWnUnG5Q-l7mNZxMRHSWrCDBfIUollCijh5HEMEXMyc6qNgn9OEb000DzimJd3VDOIdXkuo583t8YBNdHjOUMqaw19weAz3a3AYHpZs7Fb6Ej3zZizw6nJfo5-fP_043DTHb1--Hj4eG8upWJqWttYowz0jopOUd4badmCsdV3rhmHowXjKyCAccd4raYV0vlUD573wvfL8Gr0798453a9QFj2FYmEczz_VUikpBSMVZGfQ5lRKBq_nHCaT_2hK9KZZn_SmWW-at6xqrkNvLu3rMIF7HLl4rcDbC2CKNaPPJtpQHjklac-ZqNyHMwfVxe8AWRcbIFpwIYNdtEvhf3v8A2vQnc4</recordid><startdate>20060411</startdate><enddate>20060411</enddate><creator>Wan, J.B.</creator><creator>Lai, C.M.</creator><creator>Li, S.P.</creator><creator>Lee, M.Y.</creator><creator>Kong, L.Y.</creator><creator>Wang, Y.T.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060411</creationdate><title>Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction</title><author>Wan, J.B. ; Lai, C.M. ; Li, S.P. ; Lee, M.Y. ; Kong, L.Y. ; Wang, Y.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-515ca7a3f20486138a1c5b225d85dbbb9eaf120b4d0dff76c46df57b3394f97f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Calibration</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Ginsenoside</topic><topic>Ginsenosides - analysis</topic><topic>Ginsenosides - pharmacology</topic><topic>Mass Spectrometry</topic><topic>Medical sciences</topic><topic>Models, Chemical</topic><topic>Notoginsenoside</topic><topic>Panax - metabolism</topic><topic>Panax notoginseng</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - analysis</topic><topic>Plant Extracts - chemistry</topic><topic>Pressurized liquid extraction</topic><topic>Saponins - analysis</topic><topic>Saponins - chemistry</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wan, J.B.</creatorcontrib><creatorcontrib>Lai, C.M.</creatorcontrib><creatorcontrib>Li, S.P.</creatorcontrib><creatorcontrib>Lee, M.Y.</creatorcontrib><creatorcontrib>Kong, L.Y.</creatorcontrib><creatorcontrib>Wang, Y.T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wan, J.B.</au><au>Lai, C.M.</au><au>Li, S.P.</au><au>Lee, M.Y.</au><au>Kong, L.Y.</au><au>Wang, Y.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2006-04-11</date><risdate>2006</risdate><volume>41</volume><issue>1</issue><spage>274</spage><epage>279</epage><pages>274-279</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A HPLC and pressurized liquid extraction (PLE) method was developed for simultaneous determination of nine saponins, including notoginsenoside R1, ginsenoside Rg1, Re, Rf, Rb1, Rc, Rb2, Rb3 and Rd in
Panax notoginseng. The analysis was performed on C
18 column with water–acetonitrile gradient elution and the investigated saponins were authenticated by comparing retention time and mass spectra with their reference compounds. Several methods including PLE, ultrasonication, soxhlet extraction and immersion were used for sample preparation and their extraction efficiency was compared. The results showed that PLE has the highest extraction efficiency and repeatability, which would be valuable on standardization of sample preparation for quality control of Chinese medicines. The developed HPLC and PLE is an effective approach for simultaneously quantitative determination of sapoinins in
P. notoginseng, which could be used for quality control of
P. notoginseng and its preparations.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16316736</pmid><doi>10.1016/j.jpba.2005.10.023</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical and biomedical analysis, 2006-04, Vol.41 (1), p.274-279 |
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| source | ScienceDirect Journals |
| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Calibration Chemistry, Pharmaceutical - methods Chromatography Chromatography, High Pressure Liquid - methods Fundamental and applied biological sciences. Psychology General pharmacology Ginsenoside Ginsenosides - analysis Ginsenosides - pharmacology Mass Spectrometry Medical sciences Models, Chemical Notoginsenoside Panax - metabolism Panax notoginseng Pharmacology. Drug treatments Plant Extracts - analysis Plant Extracts - chemistry Pressurized liquid extraction Saponins - analysis Saponins - chemistry Spectrometry, Mass, Electrospray Ionization - methods Technology, Pharmaceutical - methods Time Factors |
| title | Simultaneous determination of nine saponins from Panax notoginseng using HPLC and pressurized liquid extraction |
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