The cold-shock response in cultured mammalian cells: Harnessing the response for the improvement of recombinant protein production

There are a growing number of reports on the sub‐physiological temperature culturing (

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Bibliographic Details
Published in:Biotechnology and bioengineering 2006-04, Vol.93 (5), p.829-835
Main Authors: Al-Fageeh, Mohamed B, Marchant, Rosalyn J, Carden, Martin J, Smales, C Mark
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotechnology
Cell Line
Cell Physiological Phenomena
Cell Proliferation
Cell Survival
Cells
Cells, Cultured
CHO Cells
Cold Temperature
cold-shock response
Cricetinae
Cricetulus
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - genetics
Gene Expression Regulation - physiology
Humans
mammalian cells
Mammals
Mice
Protein Biosynthesis - genetics
Protein Biosynthesis - physiology
Proteins
recombinant protein synthesis
Recombinant Proteins - biosynthesis
specific production rate
volumetric production
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Description
Summary:There are a growing number of reports on the sub‐physiological temperature culturing (
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.20789