Outcome following lung resections for pT1 non-small cell lung cancer

To analyse the outcome of patients with pT1 NSCLC treated at our institution by antero-lateral thoracotomy, anatomical lung resections and mediastinal lymph node dissection between 1980 and 2001. Follow-up data were obtained retrospectively from 1980 to 1990 and prospectively after 1990. Survival wa...

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Bibliographic Details
Published in:European journal of surgical oncology 2006-04, Vol.32 (3), p.329-334
Main Authors: Kopp, R., Weidenhagen, R., Reinmiedl, J., Müller, C., Fürst, H., Bittmann, I., Dienemann, H., Hatz, R.
Format: Article
Language:English
Subjects:
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - surgery
Female
Follow-Up Studies
Humans
Lung cancer
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Lung resections
Male
Middle Aged
Neoplasm Staging
NSCLC
Pneumonectomy - methods
Prospective Studies
Retrospective Studies
Survival Rate
Time Factors
Treatment Outcome
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Summary:To analyse the outcome of patients with pT1 NSCLC treated at our institution by antero-lateral thoracotomy, anatomical lung resections and mediastinal lymph node dissection between 1980 and 2001. Follow-up data were obtained retrospectively from 1980 to 1990 and prospectively after 1990. Survival was analysed using the Kaplan–Meier method. Histopathological examinations revealed mediastinal lymph node infiltration in 27.6% (pN1 17.8% and pN2 9.8%). pN2 was classified in 14.1% of adenocarcinomas compared to 6.2% of squamous cell carcinomas. Median overall survival of patients with pT1 carcinomas was 89+16 months (median+standard error). Histopathological N-classification indicates differential prognostic and therapeutic implications in pT1 adeno- and squamous cell carcinomas. Complete lymph node dissection is required for all patients with T1 NSCLC treated by either open surgery or VATS resection. Histopathological N-classification indicates differential prognostic and therapeutic implications in pT1 adeno- and squamous cell carcinomas.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2005.11.019