Simple (Imidazol-2-ylidene)-Pd-Acetate Complexes as Effective Precatalysts for Sterically Hindered Suzuki−Miyaura Couplings

A simplified synthesis of N-heterocyclic carbene (NHC)Pd-carboxylate complexes and their activity in Suzuki−Miyaura cross-coupling reactions are described. Coupling of sterically hindered aryl and activated alkyl chlorides bearing β-hydrogens has been successfully achieved.

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Bibliographic Details
Published in:Organic letters 2005-04, Vol.7 (9), p.1829-1832
Main Authors: Singh, Rohit, Viciu, Mihai S, Kramareva, Natalia, Navarro, Oscar, Nolan, Steven P
Format: Article
Language:English
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Description
Summary:A simplified synthesis of N-heterocyclic carbene (NHC)Pd-carboxylate complexes and their activity in Suzuki−Miyaura cross-coupling reactions are described. Coupling of sterically hindered aryl and activated alkyl chlorides bearing β-hydrogens has been successfully achieved.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol050472o