Prognostic Factors for Disease-Free Survival in pT2N0 Non-Small Cell Lung Cancer

To clarify the prognostic factors for disease-free survival in completely resected pT2N0 non-small cell lung cancer, 81 consecutive patients who were treated between 1998 and 2001 were retrospectively reviewed. Follow-up was complete for all patients and the median follow-up time was 37.5 months. Th...

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Bibliographic Details
Published in:Asian cardiovascular & thoracic annals 2006-04, Vol.14 (2), p.139-144
Main Authors: Park, Inkyu, Chung, Kyung Young, Kim, Kil Dong, Kim, Dae Joon
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung - diagnosis
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - therapy
Chemotherapy, Adjuvant
Cohort Studies
Disease-Free Survival
Female
Humans
Lung Neoplasms - diagnosis
Lung Neoplasms - mortality
Lung Neoplasms - therapy
Male
Middle Aged
Pneumonectomy
Retrospective Studies
Survival Rate
Tegafur
Treatment Outcome
Uracil
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Summary:To clarify the prognostic factors for disease-free survival in completely resected pT2N0 non-small cell lung cancer, 81 consecutive patients who were treated between 1998 and 2001 were retrospectively reviewed. Follow-up was complete for all patients and the median follow-up time was 37.5 months. The overall 5-year survival rate was 68.6%, and the 5-year disease-free survival rate was 62.5%. Four factors (age, sex, visceral pleural invasion, and administration of tegafur and uracil) were proposed as prognostic factors for disease-free survival by univariate analysis. In multivariate analysis, visceral pleural invasion by the tumor (hazard ratio = 2.709, 95% confidence interval: 1.085 to 6.765, p = 0.033) and administration of tegafur and uracil (hazard ratio = 0.327, 95% confidence interval: 0.147 to 0.730, p = 0.006) were significant factors. Visceral pleural invasion was a prognostic factor for reduced disease-free survival in completely resected pT2N0 non-small cell lung cancer, and postoperative treatment with tegafur and uracil significantly improved disease-free survival.
ISSN:0218-4923
1816-5370
DOI:10.1177/021849230601400212