Alkylation reactions of phosphachroman-2,4-diones and 4-hydroxy phosphacoumarins

Phosphachroman-2,4-dione and 4-alkoxyphosphacoumarin derivatives, phosphonic analogues of chromones and coumarins with potential biological activities, were synthesized in good yields through sequential base-catalyzed intramolecular cyclization of O-alkyl- O′-(2′-methoxycarbonyl phenyl)-(substituted...

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Bibliographic Details
Published in:Bioorganic chemistry 2006-04, Vol.34 (2), p.105-113
Main Authors: Li, Xueshu, Wang, Yitong, Fu, Hua, Jiang, Yuyang, Zhao, Yufen
Format: Article
Language:English
Subjects:
Alkylation
Chromans - chemistry
Coumarins - chemistry
Cyclization
Intramolecular cyclization
Magnetic Resonance Spectroscopy
Mass Spectrometry
Phosphachroman-2,4-dione
Phosphacoumarin
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Summary:Phosphachroman-2,4-dione and 4-alkoxyphosphacoumarin derivatives, phosphonic analogues of chromones and coumarins with potential biological activities, were synthesized in good yields through sequential base-catalyzed intramolecular cyclization of O-alkyl- O′-(2′-methoxycarbonyl phenyl)-(substituted) benzyl phosphonates and alkylation. The synthesis sets the stage for an examination of the biological activities.
ISSN:0045-2068
1090-2120
DOI:10.1016/j.bioorg.2006.01.003