Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines

Hexane, ethylacetate (EtOAC), and n-butanol ( n-BuOH) extracts of medicinal plants traditionally used in the East Asia, such as China, Korea, and Japan were screened for their vasorelaxant activity using isolated rat aorta. Among the 60 solvent-extracts from 20 medicinal plants, hexane and n-BuOH ex...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2005-05, Vol.99 (1), p.113-117
Main Authors: Yin, Ming Hao, Kang, Dae Gill, Choi, Deok Ho, Kwon, Tae Oh, Lee, Ho Sub
Format: Article
Language:English
Subjects:
Animals
aorta
Aorta, Thoracic - drug effects
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Enzyme Inhibitors - pharmacology
General pharmacology
In Vitro Techniques
Isometric Contraction - drug effects
Korea
Male
Medical sciences
medicinal plants
Medicine, East Asian Traditional
Muscle Tonus - drug effects
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide
Nitric Oxide Synthase - antagonists & inhibitors
Nitric Oxide Synthase Type III
Oriental medicinal plants
Oriental traditional medicine
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
plant extracts
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Rats
Rats, Sprague-Dawley
Screening
vasodilation
Vasodilator Agents - pharmacology
Vasorelaxation
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Summary:Hexane, ethylacetate (EtOAC), and n-butanol ( n-BuOH) extracts of medicinal plants traditionally used in the East Asia, such as China, Korea, and Japan were screened for their vasorelaxant activity using isolated rat aorta. Among the 60 solvent-extracts from 20 medicinal plants, hexane and n-BuOH extracts of Diospyros kaki and Polygonum aviculare, hexane, EtOAC, and n-BuOH extracts of Magnolia liliflora, n-BuOH extract of Sorbus commixta, and EtOAC and n-BuOH extracts of Selaginella tamariscina were found to exhibit distinctive vasorelaxant activity. The activity disappeared by removal of functional endothelium or pre-treatment of the aortic tissues with N G-nitro- l-arginine methyl ester ( l-NAME), which is an inhibitor of nitric oxide synthase. These findings suggest that the medicinal plants relax vascular smooth muscle via endothelium-dependent nitric oxide. These results will be useful to further analyze those medicinal plants that contain the vasorelaxant activity in order to identify the active principles.
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2005.02.013