Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters

The aim of the present study was to characterize plasma lipids and lipoprotein cholesterol and glucose concentrations in hamsters fed either cis-9, trans-11 CLA (9c, 11t CLA); trans-10, cis-12 CLA (10t, 12c CLA); or linoleic acid (LA) on the accumulation of aortic cholesterol in hypercholesterolemic...

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Bibliographic Details
Published in:Lipids 2006, Vol.41 (1), p.41-48
Main Authors: Wilson, T.A, Nicolosi, R.J, Saati, A, Kotyla, T, Kritchevsky, D
Format: Article
Language:English
Subjects:
Acclimatization
Accumulation
animal disease models
Animals
aorta
Aorta - drug effects
Aorta - metabolism
blood glucose
blood lipids
Cholesterol
Cholesterol - blood
Cholesterol - metabolism
Coconut oil
conjugated linoleic acid
Cricetinae
Diet
hamsters
hypercholesterolemia
Hypercholesterolemia - blood
Hypercholesterolemia - metabolism
Isomerism
isomers
Linoleic Acids, Conjugated - pharmacology
Lipids
Liver - metabolism
Male
Mesocricetus
triacylglycerols
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Summary:The aim of the present study was to characterize plasma lipids and lipoprotein cholesterol and glucose concentrations in hamsters fed either cis-9, trans-11 CLA (9c, 11t CLA); trans-10, cis-12 CLA (10t, 12c CLA); or linoleic acid (LA) on the accumulation of aortic cholesterol in hypercholesterolemic hamsters. One hundred male F₁B strain Syrian Golden Hamsters (Mesocricetus auratus) (BioBreeders Inc., Watertown, MA) approximately 9 wk of age were housed in individual stainless stel hanging cages at room temperature with a 12-h light/dark cycle. Hamsters were given food and water ad libitum. Following a 1-wk period of acclimation, the hamsters were fed a chow-based (nonpurified) hypercholesterolemic diet (HCD) contaning 10% coconut oil (92% saturated fat) and 0.1% cholesterol for 2 wk. After an overnight fast, the hamsters were bled and plasma cholesterol concentrations were measured. The hamsters were then divided into 4 groups of 25 based on similar mean plasma VLDL and LDL cholesterol (non HDL-C) concentrations. Group 1 remained on the HCD (control). Group 2 was fed the HCD plus 0.5% 9c, 11t CLA isomer. Group 3 was fed the HCD plus 0.5% 10t, 12c CLA isomer. Group 4 was fed the HCD plus 0.5% LA. Compared with the control, both CLA isomers and LA had significantly lower plasma total cholesterol and HDL cholesterol concentrations (P
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-006-5068-8