Absence of prognostic significance of p21(WAF1/CIP1) protein expression in non-small cell lung cancer

Prognostic value of p21WAF1/CIP1 expression in non-small-cell lung cancer patients (NSCLC) remains unclear. In this study the authors investigated the clinical significance of p21WAF1/CIP1 expression in a group of 117 NSCLC patients, who underwent curative pulmonary resection. Expression of p21WAF1/...

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Bibliographic Details
Published in:Acta oncologica 2005, Vol.44 (1), p.75-79
Main Authors: Dworakowska, Dorota, Jassem, Ewa, Jassem, Jacek, Boltze, Carsten, Wiedorn, Klaus Hermann, Dworakowski, Rafał, Skokowski, Jan, Jaśkiewicz, Kazimierz, Czestochowska, Eugenia
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers, Tumor - analysis
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - therapy
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Chemotherapy, Adjuvant
Combined Modality Therapy
Cyclin-Dependent Kinase Inhibitor p21
Female
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Lung Neoplasms - therapy
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Pneumonectomy - methods
Prognosis
Proportional Hazards Models
Radiotherapy, Adjuvant
Risk Factors
Sensitivity and Specificity
Survival Analysis
Treatment Outcome
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Summary:Prognostic value of p21WAF1/CIP1 expression in non-small-cell lung cancer patients (NSCLC) remains unclear. In this study the authors investigated the clinical significance of p21WAF1/CIP1 expression in a group of 117 NSCLC patients, who underwent curative pulmonary resection. Expression of p21WAF1/CIP1 protein was assessed immunohistochemically and samples showing>5% of positive tumor cells were considered positive. Seventy-six samples (65%) showed positive nuclear p21WAF1/CIP1 protein expression. There was no relationship between the expression of p21WAF1/CIP1 protein and major clinico-pathological factors, and neither there was an impact of p21WAF1/CIP1 protein expression on disease-free and overall survival. p21WAF1/CIP1 protein occurrence was not correlated with previously determined p53 protein expression and there was also no relationship between all possible p21WAF1/CIP1/p53 phenotypes and survival. In uni- and multivariate analysis only stage of disease was independent prognostic factors. These results suggest the lack of prognostic relevance of p21WAF1/CIP1 expression (analyzed separately or jointly with p53 protein) in surgically treated NSCLC patients.
ISSN:0284-186X
DOI:10.1080/02841860510007422