Does Earlier Headache Response Equate to Earlier Return to Functioning in Patients Suffering from Migraine?

This study explored the association between headache response and return to functioning, and identified migraine-associated symptoms related to functional status and acceptability of migraine treatment as reported by patients. Data from migraineurs enrolled in the active arms of a randomized, double...

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Bibliographic Details
Published in:Cephalalgia 2006-04, Vol.26 (4), p.428-435
Main Authors: Pradel, FG, Subedi, P, Varghese, AA, Mullins, CD, Weis, KA
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Comorbidity
Double-Blind Method
Female
functioning
headache
Headache - drug therapy
Headache - epidemiology
Humans
Incidence
Male
Maryland - epidemiology
Middle Aged
Migraine
Migraine Disorders - drug therapy
Migraine Disorders - epidemiology
Outcome Assessment (Health Care) - methods
Patient Satisfaction - statistics & numerical data
Pyrrolidines - therapeutic use
Recovery of Function
satisfaction
Serotonin Receptor Agonists - therapeutic use
Sumatriptan - therapeutic use
Treatment Outcome
Tryptamines - therapeutic use
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Summary:This study explored the association between headache response and return to functioning, and identified migraine-associated symptoms related to functional status and acceptability of migraine treatment as reported by patients. Data from migraineurs enrolled in the active arms of a randomized, double-blind, parallel group, placebo-controlled, clinical trial were analysed. The relationships between headache response and functional response, and clinical factors and treatment acceptability were assessed using X 2 tests of proportions and logistic regressions. A greater proportion of patients with headache response at 0.5 h were functioning at 0.5, 1 and 2 h compared with patients who did not attain a headache response at 0.5 h (P < 0.0001). These patients also were more likely to find their treatment acceptable (P < 0.05). The results suggest a direct temporal relationship among the key determinants of migraine resolution. Rapid headache response is associated with faster return to functioning; rapid headache and functional responses are significant attributes of treatment acceptability.
ISSN:0333-1024
1468-2982
DOI:10.1111/j.1468-2982.2005.01043.x