Silent pituitary macroadenoma co-secreting growth hormone and thyroid stimulating hormone

Silent pituitary adenomas are a group of tumors showing heterogenous morphological features with no hormonal function observed clinically. To date no explanation has been provided as to why these tumors remain “silent”. We report a case of a silent macroadenoma with both growth hormone (GH) and thyr...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2005-04, Vol.12 (3), p.318-320
Main Authors: Sen, Orhan, Ertorer, M Eda, Aydin, M Volkan, Erdogan, Bulent, Altinors, Nur, Zorludemir, Suzan, Guvener, Nilgun
Format: Article
Language:English
Subjects:
Adenoma - metabolism
Adenoma - pathology
Adenoma - surgery
Female
Glucose Tolerance Test
Human Growth Hormone - metabolism
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Middle Aged
Neurosurgical Procedures
pituitary adenoma
Pituitary Hormones - blood
Pituitary Neoplasms - metabolism
Pituitary Neoplasms - pathology
Pituitary Neoplasms - surgery
plurihormonal
silent
Thyroid Function Tests
Thyrotropin - metabolism
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Summary:Silent pituitary adenomas are a group of tumors showing heterogenous morphological features with no hormonal function observed clinically. To date no explanation has been provided as to why these tumors remain “silent”. We report a case of a silent macroadenoma with both growth hormone (GH) and thyroid stimulating hormone (TSH) staining and secretion but with no clinical manifestations, in particular, the absence of features of acromegaly or hyperthyroidism. The relevant literature is reviewed.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2004.05.011