Complications associated to severe thrombocytopenia in patients with dengue

Thrombocytopenia is a distinctive characteristic of dengue; however, few studies have related thrombocytopenia with its clinical severity. To identify the complications of dengue, associated to severe thrombocytopenia, defined as a platelets count below 50,000/mm3). Patients with clinical and serolo...

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Bibliographic Details
Published in:Revista medíca de Chile 2006-02, Vol.134 (2), p.167-173
Main Authors: Díaz-Quijano, Fredi Alexander, Villar-Centeno, Luis Angel, Martínez-Vega, Ruth Aralí
Format: Article
Language:Spanish
Subjects:
Adult
Colombia - epidemiology
Dengue - complications
Dengue - epidemiology
Epidemiologic Methods
Female
Humans
Immunoglobulin M - blood
Male
Severe Dengue - complications
Severe Dengue - epidemiology
Thrombocytopenia - complications
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Summary:Thrombocytopenia is a distinctive characteristic of dengue; however, few studies have related thrombocytopenia with its clinical severity. To identify the complications of dengue, associated to severe thrombocytopenia, defined as a platelets count below 50,000/mm3). Patients with clinical and serologic (positive IgM) diagnosis of dengue, consulting at hospitals located in Santander, Colombia, during the period 1993-1998, were studied. Clinical findings and laboratory tests (including hematocrit and platelets counts) were registered. The association between severe thrombocytopenia and the presence of complications, such as hemorrhagic manifestations (positive tourniquet test, petechiae, ecchymoses, bleeding from gums, epistaxis, hematemesis, hematuria and metrorrhagia) and signs of plasma leakage (pleural effusions and haemoconcentration), were evaluated using a univariate and multivariate analysis. Of the 790 patients enrolled, 502 had a platelet count below 50,000/mm3. Severe thrombocytopenia was associated with hemorrhagic manifestations (OR= 3.16; 95% CI: 2.09-4.76; p
ISSN:0034-9887