Coronary Sinus and Ascending Aortic Levels of Aldosterone, Angiotensin II, and B-Type Natriuretic Peptide in Patients With Aortic Stenosis and in Patients With Coronary Heart Disease

Demonstration that aldosterone synthesis occurs in the myocardium would suggest that the clinical benefits of aldosterone receptor antagonists may extend to patients with normal circulating plasma levels of aldosterone. Previous studies have reported myocardial aldosterone synthesis in patients with...

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Bibliographic Details
Published in:The American journal of cardiology 2006-04, Vol.97 (7), p.1068-1072
Main Authors: Wasywich, Cara A., Webster, Mark W.I., Richards, A. Mark, Stewart, Ralph A.H.
Format: Article
Language:English
Subjects:
Aged
Aldosterone - blood
Angiotensin II - blood
Aorta - metabolism
Aortic Valve Stenosis - blood
Aortic Valve Stenosis - physiopathology
Biological and medical sciences
Blood tests
Cardiology
Cardiology. Vascular system
Cardiovascular disease
Coronary Disease - blood
Coronary Disease - physiopathology
Coronary heart disease
Endocardial and cardiac valvular diseases
Female
Heart
Heart failure
Humans
Male
Medical imaging
Medical research
Medical sciences
Middle Aged
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Peptides
Procollagen - blood
Stroke Volume - physiology
Venae Cavae - metabolism
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Summary:Demonstration that aldosterone synthesis occurs in the myocardium would suggest that the clinical benefits of aldosterone receptor antagonists may extend to patients with normal circulating plasma levels of aldosterone. Previous studies have reported myocardial aldosterone synthesis in patients with heart failure. This study determined whether myocardial aldosterone and angiotensin II release occurs in patients with aortic stenosis (AS) and/or coronary heart disease (CHD) with normal left ventricular ejection fractions and no clinical heart failure. In 19 patients with severe AS and 18 patients with stable CHD, plasma levels of aldosterone, angiotensin II, B-type natriuretic peptide (BNP), and procollagen type III amino terminal peptide (PIIINP) were measured in blood samples taken from the coronary sinus and aortic root before diagnostic coronary angiography. Plasma aldosterone was approximately 20% greater in the coronary sinus than the aorta, respectively, in the 2 patient groups (AS: 120 vs 102 pmol/L, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.10.048